Department of Chemistry,Indian Institue of Technology Roorkee
Gnanamani Elumalai
E. Gnanamani Assistant professor
Areas of Interest
  • Organic Chemistry, Organic Synthesis, Asymmetric Catalysis:, Design and Synthesis of New Chiral Catalyst for Organo and Transition Metal Catalysis, Classical Resolution and Determination of Absolute Configuration of Chiral Compounds, ., Total Synthesis of Biologically Active Molecules, ., Microdroplet Reaction, Accelerate the Organic Reaction Rate by Utilizing the Microdroplet Chemistry
Professional Background
2018-01-012020-01-01Post Doctoral FellowStanford University, USA
2017-01-012018-01-01Post Doctoral Visiting Fellow (6 months)Fudan University (From Stanford University)
2015-01-012017-01-01Post Doctoral FellowStanford University, USA (Sponsored by Fulbright Foundation)
2013-01-012014-01-01Post Doctoral FellowInstitute of Chemistry Chinese Academy of Sciences, China
Honors and Awards
Fulbright AwardStanford University2017
Developing Country Fellowship for International Researchers AwardInstitute of Chemistry Chinese Academy of Sciences2013
Educational Details
Ph.D.ChemistryPondicherry University, Pondicherry2013
M.Phil.ChemistryPondicherry University, Pondicherry2007
M.Sc.ChemistryMadurai Kamaraj University, Madurai2006
B.Sc.ChemistryUniversity of Madars, Chennai2004
  • Fulbright Alumni, Member
  • American Chemical Society, Member
Teaching Engagements
TitleCourse CodeClass NameSemester
Organic Chemistry IVCYN-523Int. M.ScAutumn
Other work - Ph.D. and Post Doctoral positions are available, interested candidates can send an e-mail.
Refereed Journal Papers

1.      E. Gnanamani, X. Yan, R. N. Zare* "Chemoselective N-alkylation of Indoles in Aqueous Droplets", Angew. Chem. Int. Ed. 202059, 3069-3072; Angew. Chem. 2020132, 3093–3096.

2.        B. M. Trost,* E. Gnanamani, "Enantio- and Diastereoselective Double Mannich Reaction between Ynones and Imines Catalyzed by Zn-ProPhenol", Org. Lett. 2020221675-1680.

3.       B. M. Trost,* Chao-I Hung, G.  Mata, Y. Liu, Y. Lu, E. Gnanamani,  “Direct Enantio- and Diastereoselective Zn-ProPhenol Catalyzed Mannich Reactions of CF3- and SCF3-Substituted Ketones”, Org. Lett. 2020, 22, 2437-2442.

4.       B. M. Trost,* E. Gnanamani, C. A. Kalnmals, Chao-I Hung, J. Tracy, "Direct Enantio- and Diastereoselective Vinylogous Addition of Butenolides to Chromones", J. Am. Chem. Soc. 2019, 141, 1489-1493.

5.      B. M. Trost,* E. Gnanamani, Chao-I Hung, C. A. Kalnmals, "Synthesis of Chiral, Densely Substituted Pyrrolidones via Phosphine-Catalyzed Cycloisomerization", Org. Lett. 201921, 1890-1894.

6.     B. M. Trost,* Chao-I Hung, E. Gnanamani, “Tuning the Reactivity of Ketones through Unsaturation: Construction of Cyclic and Acyclic Quaternary Stereocenters", ACS Catalysis2019, 9, 1549-1557.

7.        E. D.  C. Noriega, S. Sathyamoorthi, S. Banerjee, E. Gnanamani, R. H. Pando, D. M. Espinoza, J. I. V. Bucheli, L. D. Possani, R. N. Zare* "Isolation, Synthesis, and Biological Activity of Non-Peptide Compounds from Diplocentrus melici Scorpion Venom", Proc. Natl. Acad. Sci. U S A. 2019116, 12642-12647.

8.        B. M. Trost,* Chao‐I Hung, T. Saget, E. Gnanamani “Branched Aldehydes as Linchpins for the Enantioselective and Stereodivergent Synthesis of 1,3-Aminoalcohols Featuring a Quaternary Stereocentre", Nature Catalysis, 2018, 1, 523-530.

9.        S. Banerjee, E. Gnanamani, S. Lynch, Z. Zamudio, J,-V. Fernando, V. Jimenez, L. Possani, R. N. Zare,* "An Alkaloid from Scorpion Venom: Chemical Structure and Synthesis", J. Nat. Prod.  201881, 1899-1904.

10.    B. M. Trost,* E. Gnanamani, J. S. Tracy, C. A. Kalnmals "Zn-ProPhenol Catalyzed Enantio- and Diastereoselective Direct Vinylogous Mannich Reaction Between α,β- and β, γ-Butenolides and Aldimines", J. Am. Chem. Soc. 2017139, 18198-18201.

11.       B. M. Trost,* E. Gnanamani, "Chao-I Hung “Controlling Regioselectivity in the Enantioselective N-Alkylation Reaction of Indoles Analogs Catalyzed by Dinuclear Zinc-ProPhenol”, Angew. Chem. Int. Ed. 201756, 10451-10456; Angew. Chem. 2017129,10587–10592.

12.    S. Banerjee, E. Gnanamani, X. Yan, R. N. Zare* "Can all Bulk-Phase Reactions be Accelerated in Microdroplets?", Analyst 2017142,1399-1402 (Cover Article).

13.     G. S. Kiran, S. Priyadharshini, A. D. Dobson, E. Gnanamani, J. Selvin,* "Degradation Intermediates of Polyhydroxy Butyrate Inhibits Phenotypic Expression of Virulence Factors and Biofilm Formation in Luminescent Vibrio sp. PUGSK8", npj Biofilms and Microbiomes (nature partner journal) 2016, 16002.

14.      G. S. Kiran, S. Priyadharshini, K. Anitha, E. Gnanamani, J. Selvin,*  “Characterization of an Exopolysaccharide from Probiont Enterobacter Faecalis MS112 and Effect on the Disruption of Candida Albucans Biofilm", RSC Advances 20155, 71573-71585.

15.     E. Gnanamani, N. Someshwar, J. Sanjeevi, C. R. Ramanathan,* “Conformationally Rigid Chiral Bicyclic Skeleton-Tethered Bipyridine N,N′-Dioxide as Organocatalyst: Asymmetric Ring Opening of meso-Epoxides”, Adv. Synth. Catal. 2014, 356, 2219-2223.

16.      A. Harikrishnan, J. Selvakumar, E. Gnanamani, S. Bhattacharya and C. R. Ramanathan,* “Friedel–Crafts Hydroxyalkylation Through Activation of a Carbonyl Group Using AlBr3: An Easy Access to Pyridyl Aryl/Heteroaryl Carbinols”, New J. Chem.201337, 563-567.

17.      E. Gnanamani, N. Someshwar, C. R. Ramanathan,* “Conformationally Rigid Chiral Pyridine N-Oxides as Organocatalyst: Asymmetric Allylation of Aldehydes”, Adv. Synth. Catal. 2012, 354, 2101-2106.

18.      E. Gnanamani, C. R. Ramanathan,* “Design, Synthesis, Resolution, and Stereochemical Assignment of a Conformationally Rigid Chiral Ligand Derived from Anthracene and a Dienophile Containing a Pyridine Moiety”, Tetrahedron: Asymmetry 200920, 2211-2215.


            Scorpion Venom Benzoquinone Derivatives and uses Thereof Against Multi-Drug Resistant Tuberculosis US Patent       WO 2019/231735 A


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