(Major research areas: Faculty names are given according to alphabetic order of their surnames)
Plant Biotechnology (Group Leaders: Chauhan Harsh, Randhawa G.S., Sircar Debabrata, Yadav Shri Ram)
Our department has a strong group of Plant Biotechnology perusing research on fundamental and applied aspects of plant biology in various economically important plants. Our broad research goals are understanding mechanism of plant development and abiotic stresses in crop species(such as rice, wheat, barley and guar) and improving quality and yield of rosaceous fruits (apple, pear and strawberry). We are employing SMART-cell technology, metabolic engineering, functional genomics and transgenic approaches for improvement of quality and yield of economically important cropand medicinal plants.
Biochemical Process Engineering (Group Leaders : Choudhury Bijan, Datta Saurav, Ghosh Sanjay)
In Bioprocess engineering laboratory, major activities are concerned with biotransformation using enzyme and exploring extremophiles for production of useful metabolites. Halophile is one such class of extremophile which is a good source of unique metabolites and enzymes that are yet to be commercially exploited. In the bioprocess engineering laboratory major effort has been made to culture halophile in solid state fermentation process. Unlike fungal based solid state fermentation process, halophilic solid state fermentation is rarely been developed in spite of its relative advantage. So developing halophilic culture based bioprocess is our major target. Membrane Technology and Bioengineering Laboratory is involved in both upstream and downstream bioprocess engineering. Current research activities include removal of fermentation inhibitors, production and recovery of value added biochemicals, development of functionalized membranes for enzymatic catalysis and membrane based water treatment.
Structural & Computational Biology (Group Leaders : Barthwal Ritu, Hazra Saugata, Kumar Pravindra, Mukherjee Sulakshana, Nair Maya, Poluri K.M., Sharma Deepak)
X-ray crystallography, NMR, SPR, and other biophysical techniques are being brought to bear on exciting new problems in biology through the elucidation of the functions and cellular mechanisms of diverse proteins, nucleic acids, macromolecular assemblies, and disease-related molecules. Studies aimed at elucidating biological phenomena are supported by technical developments aimed at advancing the current limits of structural biology methods. Our structurally-oriented research programs are strongly complimented by diverse studies in computational and biophysical studies. Computational studies includes algorithmic developments in different areas of bioinformatics, macromolecular structure prediction, Molecular Dynamics Simulations, designing novel therapeutics etc.
Microbiology (Group Leaders : Pathania Ranjana, Pruthi Vikash, Singh R.P.)
The fascination of understanding the life invisible to the naked eye drives tremendous research in microbiology. Here at IIT Roorkee, we are investigating various aspects of our ‘frenemies’- bacteria, fungi and algae.
We have drafted our research in the age old battle between smart pathogens and the mankind. The development and dissemination of anti-microbial resistance (AMR) is an active area of research. We employ comprehensive genomic and proteomic studies and advanced techniques like fluorescence imaging, automated microbial identification, high throughput library screening, next generation sequencing and MS-MS in state of the art biosafety facilities in our attempt to stay in sync with these fast-evolving life forms. Studies on elements of AMR like small regulatory RNA, drug efflux pumps, and discovery of novel chemical entities against new drug targets have so far been the part of our arsenal against highly drug resistant bacterial pathogens like Acinetobacter baumannii and Staphylococcus aureus. Besides novel drugs and novel drug-non-drug combinations, our researchers have made forage into Vedic history by investigating formulations based on essence of natural oils and reinventing their potential by using nano-based conjugates.
Research is also focused on friendly aspects of microbes and involves exploring these micro-factories for production of beneficial goods like biodiesel and degradation of xenobiotics. The aforementioned research is supported by funds from agencies like DBT, DST, ICMR, ICAR and MHRD.
Biochemistry & Molecular Biology (Group Leaders : Mandal P., Navani N., Prasad R., Sharma A.K.,Tomar S.)
At its most fundamental level, the study of life is the study of chemical processes. A major in biochemistry and molecular biology trains you in the experimental techniques used to probe the structures and functions of biologically important molecules. The strong laboratory and research focus of this major prepares you for graduate study or to enter careers in high-growth areas such as biotechnology and health care research.
Animal Biotechnology (Group Leaders: Ambatipudi Kiran., Roy Partha, Rohatgi Soma,Sarangi Pranita P.)
In this field of research molecular biology techniques are used to genetically engineer (i.e. modify the genome of) animals in order to improve their suitability for pharmaceutical, agricultural or industrial applications. Animal biotechnology has been used to produce genetically modified animals (GMO) that help synthesizing therapeutic proteins, have improved growth rates or showing resistance to specific disease.
Immunology & Nanotechnology (Group Leaders: Gopinath P., Rohatgi Soma, Sarangi Pranita P.)
Cell migration is in important event during various immunological responses. Following extravasation, integrin receptors expressed on the surface of immune cells interact with extracellular matrices and other ligands and mediate immune cell migration, activation, differentiation and apoptosis. Research in my laboratory focuses on studying the roles of integrin receptors and other key signalling molecules that modulate cellular functions during inflammation as well as in immune-editing events by cancer cells. Using cell culture and mouse models, we are also study different immuno-modulatory molecules with potential for future therapeutics.Study of B cells and antibodies, Development of Vaccines, Generation and characterization of murine and human monoclonal antibodies (microbial pathogens), Molecular Analysis of VDJ rearrangements at Single cell level, Antibody Repertoire studies, Clinical and Translational Immunology, Immunological case/control studies in the setting of Infectious Diseases (Fungal and/or Viral).