Sulakshana P. Mukherjee - Department of Biosciences and Bioengineering,Indian Institute of Technology Roorkee
Sulakshana P. Mukherjee
Sulakshana P.Mukherjee Assistant professor sulakshana.mukherjee@bt.iitr.ac.in +91-133228-4813
Areas of Interest
  • Structural and Molecular Biology: Protein-protein, Protein-DNA interaction, :-------using NMR, various biophysical and biochemical methods
Professional Background
FromPeriodPositionOrganisation
2014-01-01OngoingAssistant ProfessorIIT-Roorkee
2013-01-011 year Research AssociateThe Scripps Research Institute, California
2013-01-011 year Visiting ScholarUniversity of California, San Diego
2011-01-012 years Assistant Research ScientistUniversity of California, San Diego
2011-01-01Professional Scientific CollaboratorThe Scripps Research Institute, California
2006-01-015 years Post doctoral FellowUniversity of California, San Diego
2005-01-01Visiting ScholarUniversity at Buffalo, The State University of New York
Multiple Posts
FromPeriodPositionOrganisation
2015-08-141 year 9 months WardenKastuba Bhawan
Honors and Awards
AwardInstituteYear
Irvington Institute Postdoctoral FellowshipCancer Research Institute2012
TAA-Zita Lobo Memorial Award for the best thesis of the yearTata Institute of Fundamental Research2007
Sarojini Damodaran International FellowshipTata Institute of Fundamental Research2005
Best oral presentation awardRSC-West India Section2005
Educational Details
DegreeSubjectUniversityYear
PhDChemical SciencesTata Institute of Fundamental Research, Mumbai2006
MScInorganic ChemistryMumbai University2000
BScChemistryMumbai University1998
Sponsored Research Projects
TopicFunding AgencyStart DatePeriod
Role of NF-kappaB dimer dynamics in NF-kappaB driven transcriptionDST-SERB2015-11-263 years 2 months 30 days
Molecular Mechanism of transcription activation of genes repressed by NF-kappaBDBT, India2019-01-102 years 11 months 30 days
Participation in seminars
NamePlaceSponsored ByDate
Structure-Function Analysis of NF-kappaB interactions in transcription regulationTIFR, MumbaiTIFR, Mumbai2015-01
Structural basis for the functional role of RelA:CBP/p300 interaction in RelA driven transcriptionUniversity of California, San DiegoCancer/Mammals club2013-01
Insights into the RelA:CBP interaction in transcription regulationWhistler, CanadaKeystone symposia: NF-kappaB Signaling and Biology: From Bench to Bedside2012-01
Memberships
  • National Magnetic Resonance Society of India, Life Member
  • Indian Biophysical Society, Life Member
Teaching Engagements
TitleCourse CodeClass NameSemester
Case StudyBTN-300B-Tech IIISpring
BioinformaticsBT-630PGSpring
NMR in Medicine and BiologyBT-640PGSpring
Molecular BiophysicsBTN-442UGAutumn
Molecular BiophysicsBTN-521PGSpring
Chemical Kinetics and Reactor DesignBTN-292B-Tech IIISpring
PHDs Supervised
TopicScholar NameStatus of PHDRegistration Date
Characterization of NF-kappaB dimer specificity on gene regulationNitin DhakaO2018-07
Role of NF-kappaB interactions with its binding partners in NF-kappaB driven transcriptionTahseen RazaA2014-07
Role of NF-kappaB dynamics in NF-kappaB driven transcriptionManish KumarA2015-01
Refereed Journal Papers
  1. Raza T, Dhaka N, Joseph D, Dadhwal, Kakita, Atreya HS, Mukherjee SP*. Insights into the NF-κB-DNA Interaction through NMR Spectroscopy. ACS Omega, 6, (2021),12877–12886
  2. Kumar M, Dhaka N, Raza T, Dadhwal P, Atreya HS, Mukherjee SP*. Domain Stability Regulated through the Dimer Interface Controls the Formation Kinetics of a Specific NF-κB Dimer. Biochemistry, 60, (2021), 513-523
  3. Kumar M, Dadhwal P, Atreya HS and Mukherjee SP*. Backbone Resonance Assignments of the Dimeric Domain of the p50 NF-kappaB Subunit. (2020) Biomol NMR Assign 14:9-11
  4. Mulleti S, Singh A, Brahmkhatri VP, Chandra K, Raza T, Mukherjee SP, Seelamantula CS, Atreya HS. Super-Resolved Nuclear Magnetic Resonance Spectroscopy. (2017) Sci Rep 7:9651
  5. Mukherjee SP, Quintas PO, McNulty R, Komives EA, Dyson HJ. Structural characterization of the ternary complex that mediates termination of NF-kB signaling by IkBa. (2016) Proc Natl Acad Sci USA 113:6212-7
  6. Mukherjee SP, Borin B, Quintas PO, Dyson HJ. NMR Characterization of a 72 kDa transcription factor using differential isotopic labeling. (2016) Protein Sci. 25:597-604
  7. Mukherjee SP, Behar M, Birnbaum HA, Hoffmann A, Wright PE and Ghosh G. Structural analysis of the RelA:CBP/p300 interaction reveals its functional role in RelA-driven transcription. (2013) Plos Biol 11(9).
  8. Mohan PM, Mukherjee S, Chary KV. Differential native state ruggedness of the two Ca2+-binding domains in a Ca2+ sensor protein (2008) Proteins 70:1147-53.
  9. Mukherjee S, Mohan PM, Kuchroo, K, Chary KV. Energetics of Native Energy Landscape of a Two-domain Calcium Sensor Protein: Distinct Folding Features of the Two Domains. (2007) Biochemistry 46:9911-9.
  10. Mukherjee S, Mohan PM, and Chary KV. Magnesium promotes conformational switching action of a Calcium sensor protein. (2007) Biochemistry 46:3835-45
  11. Mukherjee S, Muralidhar D, Atreya HS, Szyperski T, Jeromin A, Sharma Y, Chary KV. Letter to the Editor: 1H, 13C and 15N resonance assignments for the myristoylated neuronal calcium sensor (NCS-1). (2006)  J.Biomol.NMR 36 Suppl 5:48
  12. Mustafi SM, Mukherjee S, Chary KV, Cavallaro G. Structural basis for the observed differential magnetic anisotropic tensorial values in calcium binding proteins. (2006) Proteins 65:656-69
  13. Mukherjee S, Fairwell T, Sharma Y, Chary KV. Importance of a single hydrophobic residue in calcium binding affinity to EF-hand peptides. (2006) Calcium Binding Proteins 1:115-19
  14. Mukherjee S, Kuchroo K, Chary KV. Structural characterization of the apo form of a calcium binding protein from Entamoeba histolytica by hydrogen exchange and its folding to the holo state. (2005) Biochemistry 44: 11636-45
  15. Mukherjee S, Mustafi SM, Atreya HS, Chary KV. Measurement of 1J(Ni, Cai), 1J(Ni, C’i-1), 2J(Ni, Cai-1), 2J(HNi, C’i-1) and 2J(HNi, Cai) values in 13C/15N labeled proteins. (2005) Magn Reson Chem. 43:326-329
  16. Mukherjee S, Mustafi SM, Sheth AA, Atreya HS, Chary KV. NMR of EF-hand calcium binding proteins. (2004) Proc Indian Natn Sci Acad, 70A: 615-25 (Review Article)
  17. Mustafi SM, Mukherjee S, Chary KV, Bianco CD, Luchinat C. Energetics and Mechanism of Ca2+ displacement by lanthanides in a calcium binding protein. (2004) Biochemistry 43: 9320-31
  18. Atreya HS, Mukherjee S, Chary KV, Lee YM, Luchinat C. Structural basis for sequential displacement of Ca2+ by Yb3+ in a protozoan EF-hand calcium binding protein. (2003) Protein Sci. 12:412-25
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