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Saugata Hazra
Saugata Hazra Assistant Professor shazrfbt[at]iitr.ac.in +91-1332-284800 Website
Areas of Interest
  • Structural Biology, Protein crystallography, Structure based drug development
  • Enzymology, Enzyme kinetics, Biophysical & biochemical studies, Structure-function relationship
  • Computational Biology, MD simulation, Virtual screening, Macromolecular interaction
Professional Background
FromToDesignationOrganisation
20112014Postdoctoral Research AssociateAlbert Einstein College of Medicine, New York, USA
20102011Postdoctoral Research FellowSt Jude Children's Research Hospital, Memphis, USA
Educational Details
DegreeSubjectUniversityYear
Ph.D.Protein Engineering, Structural Biology & Drug DesigningUniversity of Illinois at Chicago2010
M.Tech.Biotechnology and Biochemical EngineeringIIT-Kharagpur2004
M.Sc.Biophysics & Molecular BiologyUniversity of Calcutta2002
B.Sc.Chemistry (Hons.)University of Calcutta2000
Sponsored Research Projects
TopicFunding AgencyYear
Identification and characterization of novel inhibitors against medicinally important beta-lactamaseDeanSRIC, IIT-Roorkee2014
Development of Novel therapeutics against drug resistant beta-lactamases.SERB, DST2015
Developing novel antimicrobial therapeutics by exploring multi-enzyme targets.ICMR2017
Memberships
  • American Chemical Society (ACS), Member
  • National Network for Mathematical and Computational Biology (NNMCB), Member
Teaching Engagements
TitleCourse CodeClass NameSemester
BIOINFORMATICSBT-205UGAutumn
MACROMOLECULAR CRYSTALLOGRAPHYIBT-02UGAutumn
BIOINFORMATICSBTN-630PGSpring
MACROMOLECULAR CRYSTALLOGRAPHYIBT-02UGSpring
BIOMOLECULAR MODELLINGBT-460UGAutumn
Research Scholar Groups
Scholar NameInterest
Dr. Swati MohapatraMicrobiology, Protein Chemistry, Drug Screening
Gazal KalyanProtein Structure Based Programing Tool Development
Refereed Journal Papers
  1. Divya Bandekar, Om Prakash Chouhan, Swati Mohapatra, Mousumi Hazra, Saugata Hazra, Sumit Biswas. “Putative Protein VC0395_0300 from Vibrio cholerae is a Diguanylate Cyclase with a Role in Biofilm Formation”. Microbiological Research, 2017. (Just accepted)
  2. Vishal Das, Gazal Kalyan, Mintu Pal, Saugata Hazra. “Understanding the Role of Structural Integrity and Differential Expression of Integrin Profiling to Identify Potential Therapeutic Targets in Breast Cancer”. Journal of Cellular Physiology, 2017. [Epub ahead of print]
  3. Sachin Bharatiy, Mousumi Hazra, Manish Paul, Swati Mohapatra, Deviprasad Samantaray, Ramesh Chandra Dubey,  Shourjya Sanyal,  Saurav Datta, Saugata Hazra. "In silico designing of an industrially sustainable carbonic anhydrase using Molecular Dynamics Simulation". ACS Omega, 2016. 1:1081-103.
  4. Wang Wang, Shaun M. K. McKinnie, Maikel Farhan, Manish Paul, Tyler McDonald, Brent McLean, Saugata Hazra, Allan G. Murray, John C. Vederas and Gavin Y. Oudit.  “Angiotensin Converting Enzyme 2 Metabolizes and Partially Inactivates Pyrapelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System”. Hypertension, 2016. 68:365-77.
  5. Om Prakash Chouhan, Divya Bandekar, Mousumi Hazra, Ashish Baghudana, Saugata Hazra, Sumit Biswas. "Effect of site-directed mutagenesis at the GGEEF domain of the biofilm forming GGEEF protein from Vibrio cholerae". AMB Express, 2016. 6:2.
  6. Saugata Hazra*, Sebastian Kurz*, Kerstin Wolff, Liem Nguyen, Robert Bonomo, John S. Blanchard: “Kinetic and Structural Characterization of the Interaction of the 6-methylidene penem 2 with the β-Lactamase from Mycobacterium tuberculosis”. Biochemistry, 2015. 54:5657-64. (* contributed equally).
  7. Sebastian Kurz*, Saugata Hazra*, Christopher Bethel, Chiara Romagnoli, Emilia Caselli, Fabio Prati, John S. Blanchard, Robert Bonomo: “Inhibiting the β-Lactamase of Mycobacterium tuberculosis (Mtb) with Novel Boronic-Acid-Transition-State-Inhibitors (BATSIs)”. ACS Infectious Diseases, 2015. 1:234-42. (* contributed equally)
  8. Ratnadeep Basu, Saugata Hazra, Miriam Shanks, David I. Paterson, Gavin Y. Oudit. "Novel mutation in exon 14 of the sarcomere gene MYH7 in familial left ventricular noncompaction with bicuspid aortic valve". Circulation: Heart Failure, 2014. 7:1059-62.
  9. Saugata Hazra, Hua Xu, John S. Blanchard: “Tebipenem, a New Carbapenem Antibiotic is a Slow Substrate that Inhibits the β-Lactamase from Mycobacterium tuberculosis”. Biochemistry, 2014. 53:3671-8.
  10. Saugata Hazra*, Timin Hadi*, John S. Blanchard, Martin E. Tanner. “The Structure of MurNAc 6-Phosphate Hydrolase (MurQ) from Haemophilus influenzae with Bound Inhibitor”. Biochemistry, 2013. 23:9358-66. (* co-first author)
  11. Sebastian Kurz, Kerstin Wolff, Saugata Hazra, Christopher Bethel, Andrea Hujer, Kerri Smith, Yan Xu, Lee Tremblay, John S. Blanchard, Liem Nguyen, Robert Bonomo: “Can inhibitor resistant substitutions in the Mycobacterium tuberculosis β-lactamase BlaC lead to clavulanate resistance? A biochemical rationale for the use of β-lactam β-lactamase inhibitor combinations”. Antimicrobial Agents and Chemotherapy, 2013. 57:6085-96.
  12. Manish Paul, Mousumi Hazra, Arghya Barman, Saugata Hazra#: “Comparative molecular dynamics simulation studies for determining factors contributing to the thermostability of chemotaxis protein CheY”. JBSD. 2013. 32:928-49. (# corresponding author)
  13. Christine E. Quartararo, Saugata Hazra, Timin Hadi, John S. Blanchard. “Structural, kinetic and chemical mechanism of isocitrate dehydrogenase-1 from Mycobacterium tuberculosis”. Biochemistry. 2013. 52:1765-75.
  14. Hua Xu, Saugata Hazra, John S. Blanchard: “NXL104 Irreversibly inhibits the β-Lactamase from Mycobacterium tuberculosis”. Biochemistry. 2012. 51:4551-7.
  15. Saugata Hazra, Andrzej Szewczak, Stephen Ort, Manfred Konrad, Arnon Lavie.: “Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release”. Biochemistry. 2011. 50:2870-80.
  16. Saugata Hazra, Manfred Konrad, Arnon Lavie.: “The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analogues”. JMC. 2010. 53:5792-800.
  17. Saugata Hazra, Stephen Ort, Manfred Konrad, Arnon Lavie.: “Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues”. Biochemistry. 2010. 49:6784-90.
  18. Saugata Hazra, Elisabetta Sabini, Stephen Ort, Manfred Konrad, Arnon Lavie.: “Extending Thymidine Kinase Activity to the Catalytic Repertoire of Human Deoxycytidine Kinase”. Biochemistry. 2009. 48:1256-63.
  19. Elisabetta Sabini, Saugata Hazra, Manfred Konrad, Arnon Lavie: “Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase”. JMC. 2008. 51:4219-25.
  20. Elisabetta Sabini, Saugata Hazra, Stephen Ort, Manfred Konrad, Arnon Lavie: “Structural basis for substrate promiscuity of dCK”. JMB. 2008. 378:607-21.
  21. Theresa McSorley, Stephan Ort, Saugata Hazra, Arnon Lavie, Manfred Konrad: “Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues”. FEBS Letter. 2008. 582:720-4.
  22. Elisabetta Sabini, Saugata Hazra, Manfred Konrad, Arnon Lavie: “Nonenantio selectivity Property of Human Deoxycytidine Kinase Explained by Structures of the Enzyme in Complex with l- and d-Nucleosides”. JMC. 2007. 50:3004-14.
  23. Elisabetta Sabini, Saugata Hazra, Manfred Konrad, Arnon Lavie: “Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase”. NAR. 2007. 35: 186-92. (Honored as a cover article).

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