- Structural Biology, Protein crystallography, Structure based drug development
- Enzymology, Enzyme kinetics, Biophysical & biochemical studies, Structure-function relationship
- Computational Biology, MD simulation, Virtual screening, Macromolecular interaction
| From | To | Designation | Organisation |
|---|---|---|---|
| 2011 | 2014 | Postdoctoral Research Associate | Albert Einstein College of Medicine, New York, USA |
| 2010 | 2011 | Postdoctoral Research Fellow | St Jude Children's Research Hospital, Memphis, USA |
| Award | Institute | Year |
|---|---|---|
| Frontiers of Engineering for Development | Royal Academy of Engineering, UK | 2017 |
| Degree | Subject | University | Year |
|---|---|---|---|
| Ph.D. | Protein Engineering, Structural Biology & Drug Designing | University of Illinois at Chicago | 2010 |
| M.Tech. | Biotechnology and Biochemical Engineering | IIT-Kharagpur | 2004 |
| M.Sc. | Biophysics & Molecular Biology | University of Calcutta | 2002 |
| B.Sc. | Chemistry (Hons.) | University of Calcutta | 2000 |
| Topic | Funding Agency | Year |
|---|---|---|
| Identification and characterization of novel inhibitors against medicinally important beta-lactamase | MHRD | 2014 |
| Development of Novel therapeutics against drug resistant beta-lactamases. | SERB, DST | 2015 |
| Developing novel antimicrobial therapeutics by exploring multi-enzyme targets. | ICMR | 2017 |
| Edible oil blend from lignocellulosic pentosans and other inexpensive raw materials. | DBT-BIRAC | 2018 |
- American Chemical Society (ACS), Member
- National Network for Mathematical and Computational Biology (NNMCB), Member
| Title | Course Code | Class Name | Semester |
|---|---|---|---|
| BIOINFORMATICS | BT-205 | UG | Autumn |
| MACROMOLECULAR CRYSTALLOGRAPHY | IBT-02 | UG | Autumn |
| BIOINFORMATICS | BTN-630 | PG | Spring |
| MACROMOLECULAR CRYSTALLOGRAPHY | IBT-02 | UG | Spring |
| BIOMOLECULAR MODELLING | BT-460 | UG | Autumn |
| Nanoscale Modeling and Simulation | NTN-504 | Nanoscale Modeling and Simulation | Spring |
| Computational Biology | BTN-664 | Computational Biology | Spring |
| Biotechnology Laboratory (II) | BTN-304 | Biotechnology Laboratory (II) | Spring |
| Training Seminar | BTN-499 | Training Seminar | Autumn |
| Scholar Name | Interest |
|---|---|
| Dr. Swati Mohapatra | Screening of high yield producers of biodegradable polymer |
| Gazal Kalyan | Protein Structure Based Programing Tool Development |
| Gireesh Kumar Shroti | Screening, isolation and characterization of biodegradable polymer from waste resources |
| Preeti Tomer | Screening, isolation and characterization of biodegradable polymer from waste resources |
| Vivek Junghare | Modeling and dynamics of peptides and their role in understanding protein function |
| Niteesh Kumar Pandey | Cloning, purification and characterization of serine protease inhibitors |
| Sourya Bhattacharya | Understanding Class-A beta lactamase towards drug resistance |
| Couse Name | Sponsored By | Date |
|---|---|---|
| Methods and techniques in integrated Structural Biology: Toward structure based drug development | MHRD Scheme on Global Initiative on Academic Network (GIAN) | 15.01.2018 |
| Topic | Organisation | Level |
|---|---|---|
| In detailed study of food derived peptides and designed peptidomimetics towards therapeutics | University of Nebraska-Lincoln, USA | RP |
| Development of biodegradable green polymers as 3D printing materials. | University College London, UK | RP |
| Surface fluidics and low cost microscopy for point of care microbial diagonostics in low resource settings. | University College London, UK | RP |
| Edible oil blend from lignocellulosic and other inexpensive raw materials | IIP, Dehradun, India | RP |
| (A) Unravelling the mechanism for cross talk of signalling pathways involving epithelial mesenchymal transition (EMT) in cancer metastasis. (B) Studying the anticancer activity of dendrimer based nanobot drugs. | CSIR-NEIST, Jorhat, Assam, India | RP |
| Structure-function understanding of proteins involved in biofilm formation. | BITS-Pilani, Goa, India | RP |
| Developing computational tools for studying macromolecules and macromolecular interactions. | Nanyang Technological University, Singapore | RP |
| (A) Studying cattle genome and proteome during environmental thermal stress. (B) Functional genomic and proteomic analysis of cross breed bull spermatozoa. | ICAR - CENTRAL INSTITUTE FOR RESEARCH ON CATTLE (CIRC), Meerut, India | RP |
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Singh R, Sengar G, Singh U, Deb R, Junghare V, Hazra S, Kumar S, Tyagi S, Das A, Raja T, Kumar A. Functional proteomic analysis of crossbred (Holstein Friesian × Sahiwal) bull spermatozoa. Reproduction in Domestic Animals. 2018.
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Bandhu S, Khot M, Sharma T, Sharma O, Dasgupta D, Mohapatra S, Hazra S, Khatri O, Ghosh D. Single Cell Oil from Oleaginous Yeast Grown on Sugarcane Bagasse-Derived Xylose: An Approach toward Novel Biolubricant for Low Friction and Wear. ACS Sustainable Chemistry & Engineering. 2017;6(1):275-283.
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Bandekar D, Chouhan O, Mohapatra S, Hazra M, Hazra S, Biswas S. Putative protein VC0395_0300 from Vibrio cholerae is a diguanylate cyclase with a role in biofilm formation. Microbiological Research. 2017;202:61-70.
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Das V, Kalyan G, Hazra S, Pal M. Understanding the role of structural integrity and differential expression of integrin profiling to identify potential therapeutic targets in breast cancer. Journal of Cellular Physiology. 2017;233(1):168-185.
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Bharatiy S, Hazra M, Paul M, Mohapatra S, Samantaray D, Dubey R, Sanyal S, Datta S, Hazra S. In Silico Designing of an Industrially Sustainable Carbonic Anhydrase Using Molecular Dynamics Simulation. ACS Omega. 2016;1(6):1081-1103.
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Wang W, McKinnie S, Farhan M, Paul M, McDonald T, McLean B, Llorens-Cortes C, Hazra S, Murray A, Vederas J, Oudit G. Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17Novelty and Significance. Hypertension. 2016;68(2):365-377.
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Chouhan O, Bandekar D, Hazra M, Baghudana A, Hazra S, Biswas S. Effect of site-directed mutagenesis at the GGEEF domain of the biofilm forming GGEEF protein from Vibrio cholerae. AMB Express. 2016;6(1).
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Hazra S, Kurz S, Wolff K, Nguyen L, Bonomo R, Blanchard J. Kinetic and Structural Characterization of the Interaction of 6-Methylidene Penem 2 with the β-Lactamase from Mycobacterium tuberculosis. Biochemistry. 2015;54(36):5657-5664.
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Kurz S, Hazra S, Bethel C, Romagnoli C, Caselli E, Prati F, Blanchard J, Bonomo R. Inhibiting the β-Lactamase of Mycobacterium tuberculosis (Mtb) with Novel Boronic Acid Transition-State Inhibitors (BATSIs). ACS Infectious Diseases. 2015;1(6):234-242.
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Basu R, Hazra S, Shanks M, Paterson D, Oudit G. Novel Mutation in Exon 14 of the Sarcomere Gene MYH7 in Familial Left Ventricular Noncompaction With Bicuspid Aortic Valve. Circulation: Heart Failure. 2014;7(6):1059-1062.
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Hazra S, Xu H, Blanchard J. Tebipenem, a New Carbapenem Antibiotic, Is a Slow Substrate That Inhibits the β-Lactamase from Mycobacterium tuberculosis. Biochemistry. 2014;53(22):3671-3678.
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Hadi T, Hazra S, Tanner M, Blanchard J. Structure of MurNAc 6-Phosphate Hydrolase (MurQ) from Haemophilus influenzae with a Bound Inhibitor. Biochemistry. 2013;52(51):9358-9366.
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Kurz S, Wolff K, Hazra S, Bethel C, Hujer A, Smith K et al. Can Inhibitor-Resistant Substitutions in the Mycobacterium tuberculosis β-Lactamase BlaC Lead to Clavulanate Resistance?: a Biochemical Rationale for the Use of β-Lactam–β-Lactamase Inhibitor Combinations. Antimicrobial Agents and Chemotherapy. 2013;57(12):6085-6096.
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Paul M, Hazra M, Barman A, Hazra S. Comparative molecular dynamics simulation studies for determining factors contributing to the thermostability of chemotaxis protein “CheY”. Journal of Biomolecular Structure and Dynamics. 2013;32(6):928-949.
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Quartararo C, Hazra S, Hadi T, Blanchard J. Structural, Kinetic and Chemical Mechanism of Isocitrate Dehydrogenase-1 from Mycobacterium tuberculosis. Biochemistry. 2013;52(10):1765-1775.
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Xu H, Hazra S, Blanchard J. NXL104 Irreversibly Inhibits the β-Lactamase from Mycobacterium tuberculosis. Biochemistry. 2012;51(22):4551-4557.
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Hazra S, Szewczak A, Ort S, Konrad M, Lavie A. Post-Translational Phosphorylation of Serine 74 of Human Deoxycytidine Kinase Favors the Enzyme Adopting the Open Conformation Making It Competent for Nucleoside Binding and Release. Biochemistry. 2011;50(14):2870-2880.
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Hazra S, Konrad M, Lavie A. The Sugar Ring of the Nucleoside Is Required for Productive Substrate Positioning in the Active Site of Human Deoxycytidine Kinase (dCK): Implications for the Development of dCK-Activated Acyclic Guanine Analogues. Journal of Medicinal Chemistry. 2010;53(15):5792-5800.
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Hazra S, Ort S, Konrad M, Lavie A. Structural and Kinetic Characterization of Human Deoxycytidine Kinase Variants Able To Phosphorylate 5-Substituted Deoxycytidine and Thymidine Analogues. Biochemistry. 2010;49(31):6784-6790.
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Hazra S, Sabini E, Ort S, Konrad M, Lavie A. Extending Thymidine Kinase Activity to the Catalytic Repertoire of Human Deoxycytidine Kinase. Biochemistry. 2009;48(6):1256-1263.
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Sabini E, Hazra S, Konrad M, Lavie A. Elucidation of Different Binding Modes of Purine Nucleosides to Human Deoxycytidine Kinase. Journal of Medicinal Chemistry. 2008;51(14):4219-4225.
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Sabini E, Hazra S, Ort S, Konrad M, Lavie A. Structural Basis for Substrate Promiscuity of dCK. Journal of Molecular Biology. 2008;378(3):607-621.
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McSorley T, Ort S, Hazra S, Lavie A, Konrad M. Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues. FEBS Letters. 2008;582(5):720-724.
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Sabini E, Hazra S, Konrad M, Lavie A. Nonenantioselectivity Property of Human Deoxycytidine Kinase Explained by Structures of the Enzyme in Complex with L- and D-Nucleosides. Journal of Medicinal Chemistry. 2007;50(13):3004-3014.
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Sabini E, Hazra S, Konrad M, Burley S, Lavie A. Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase. Nucleic Acids Research. 2006;35(1):186-192.
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