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Ranjana Pathania
Ranjana Pathania Associate Professor rpathfbs[at] 01332-285324
Areas of Interest
  • Molecular Biology, Bacterial Pathogenesis, Role of Small RNA in Acinetobacter baumannii, Antibacterial Drug Discovery, Chemical Genomics, Mode of Action of Novel Antibacterials in Gram
  • -negative bacteria, Multiple Drug Resistance in Bacteria, Discovery of Novel Efflux Pump Inhibitors, Antisense RNA based therapeutic strategies against bacterial pathogens, Pathogenesis of A. baumannii
  • Bioremediation of Pesticide contaminated soil, Characterization of Pesticide degrading Bacteria, Metagenomics
Professional Background
April,2014PresentAssociate ProfessorDepartment of Biotechnology, Indian Insitute of Technology Roorkee
Oct, 2007April,2014Assistant ProfessorDepartment of Biotechnology, Indian Institute of Technology Roorkee
Nov, 2003Oct, 2007Postdoctoral Research FellowDepartment of Biochemistry and Biomedical Sciences, McMaster University, ON, Canada
May, 2003Nov, 2003Postdoctoral Research FellowProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Sponsored Research Projects
TopicFunding AgencyYear
Chemical genetic approaches for the discovery of novel antibacterials against antibiotic Gram-negatiSERB2018
Detection and Inhibition of clinically relevant carbapenemaseICMR-RCN (Indo-Norway)2018
Interplay of small RNAs and Hfq in gene expression control in Acinetobacter baumannii: novel mechaniDBT2016
Chemical genetic approach for discovery of new chemical entities against multiple drug resistant (MDICMR2015
Development of a bacterial pesticide degrading system for bioremediation of pesticides accumulated iUCOST2015
Hazard characterization and isolation of pesticide degrading bacteria for mitigating the environmentUCOST2011
Research Scholar Groups
Scholar NameInterest
Atin SharmaNon-coding RNA in Acinetobacter baumannii, drug efflux pumps
Timsy BhandoNon-coding RNA in A.baumannii, Mechanism of action of Antibacterial small molecules
Amit GauravNatural Products, Antibiotic combinations
Vineet DubeyRegulatory small RNA in Acinetobacter baumannii, Novel drug combinations against resistant bacteria
Jawed AkhterMode of action of novel antibacterial agents
Mahak SainiChemcial genetics, antibacterial drug discovery
Somok BhowmiksRNA in Acinetobacter baumannii, Metal ion transporters in parthenogenesis
Kuldip DevnathsRNA in Acinetobacter baumannii, Nanomaterial conjugates
Satvika SharmaScreening of carbapenemase inhibitors
PHDs Supervised
TopicScholar NameStatus of PHDRegistration Year
Studies on small RNA based regulation of stress response in A. baumanniiSomok BhowmikO2016
Chemcial genetics for NCE and antibacterial drug discovery (putative)Mahak SainiO2015
Deciphering the mode of action and pharmacokinetic potential of novel antibacterial agentsJawed AkhterO2014
Studies on the role of small RNA in physiology of Acinetobacter baumanniiVineet DubeyO2014
Studies on combinations of antibacterial molecules against MDR Acinetobacter baumanniiAmit GauravO2014
Identification and characterization of small RNA from the genetic islands of Acinetobacter baumanniiTimsy BhandoO2013
Studies on novel small RNA and their targets in Acinetobacter baumanniiAtin SharmaA2012
Chemical genetic approaches to combat multi drug resistance in Gram negative bacteriaTapas BhattacharyyaA2010
Metagenomic approach to study microbes from Himalayan geothermal springsJitendra Kumar SahooA2009
Antibacterial activity of soil bacilli and potential of essential ‘Y’ genes as drug targetsSupriya Deepak PatilA2008
Identification and characterization of small RNA from Acinetobacter baumannii MTCC 1425Rajnikant SharmaA2008
Refereed Journal Papers
  • Sharma, A., Dubey, V., Sharma, R., Devnath, K., Gupta, V.K., Akhter, J., Bhando, T., Verma, A., Ambatipudi, K.S., Sarkar, M., Pathania, R. (2018). The unusual glycine rich C-terminus of the Acinetobacter baumannii RNA chaperone Hfq plays an important role in bacterial physiology, Journal of Biological Chemistry, 293, 13377-13388
  • Gupta, V. K., Gaur, R., Sharma, A., Akther, J., Saini, M., Bhakuni, R. S., & Pathania, R. (2018). A novel bi-functional chalcone inhibits multi-drug resistant Staphylococcus aureus and potentiates the activity of fluoroquinolones. Bioorganic Chemistry. j.bioorg.2018.10.024.
  • Sharma, A., Sharma, R., Bhattacharyya, T., Bhando, T., Pathania, R. (2017).Fosfomycin resistance in Acinetobacter baumannii is mediated by efflux through a major facilitator superfamily (MFS) transporter—AbaF, Journal of Antimicrobial Chemotherapy, 72, 68–74.
  • Bhattacharyya, T., Sharma, A., Akhter, J., & Pathania, R. (2017). The small molecule IITR08027 restores the antibacterial activity of fluoroquinolones against multidrug-resistant Acinetobacter baumannii by efflux inhibition. International journal of antimicrobial agents50(2), 219-226.
  • Srivastava, S. K., Iyer, V. R., Ghosh, T., Lambadi, P. R., Pathania, R., & Navani, N. K. (2016). Isolation of a non-genomic origin fluoroquinolone responsive regulatory element using a combinatorial bioengineering approach. Nucleic acids research. 44(5), 2451-2461.
  • Lambadi, P. R., Sharma, T. K., Kumar, P., Vasnani, P., Thalluri, S. M., Bisht, N., Pathania, R. and Navani, N. K. (2015). Facile biofunctionalization of silver nanoparticles for enhanced antibacterial properties, endotoxin removal, and biofilm control. International journal of nanomedicine. 10, 2155.
  • Srivastava, S. K., Lambadi, P. R., Ghosh, T., Pathania, R., & Navani, N. K. (2014). Genetic regulation of spy gene expression in Escherichia coli in the presence of protein unfolding agent ethanol. Gene. 548(1), 142-148.
  • Sharma, R., Arya, S., Patil, S. D., Sharma, A., Jain, P. K., Navani, N. K., & Pathania, R. (2014). Identification of novel regulatory small RNAs in Acinetobacter baumannii. PloS one. 9(4), e93833.
  • Sharma, R., Arya, S., Patil, S.D., Sharma, A., Jain, P.K., Navani, N.K. and Pathania, R. Identification of novel regulatory small RNAs in Acinetobacter baumannii. PLoS ONE 9(4): e93833. doi:10.1371/journal.pone.0093833
  • Patil, S.D., Sharma, R., Srivastava, S.K., Navani, N.K. and Pathania, R. (2013) Downregulation of yidC in Escherichia coli by antisense RNA expression results in sensitization to antibacterial essential oils eugenol and carvacrol. PLoS ONE. 8(3), e57370.
  • Ghosh, I., Patil, S.D., Sharma, T.K., Srivastava, S.K., Pathania, R. and Navani, N.K. (2013) Synergistic action of cinnamaldehyde with silver nanoparticles against spore-forming bacteria; a case for judicious use of silver nanoparticles for antibacterial applications. International Journal of Nanomedicine .8, 4721-4731.
  • Iyer, V.R., Sharma, R., Pathania, R. and Navani, N.K. (2012) Small RNAs of Pathogenic Bacteria: Not Small Enough to be overlooked for Therapeutics. Molecular and Cellular Pharmacology .4(1), 17-30.
  • Sharma, T.K., Sapra, M., Chopra, A., Sharma, R., Patil, S.D., Pathania, R. and Navani, N.K. (2012) Interaction of bacteriocin-capped silver nanoparticles with food pathogens and their antibacterial effect. International Journal of Green Nanotechnology. 4(2), 93-110.
  • Sharma, T.K., Chopra, A., Sapra, M., Kumawat, D., Patil, S.D., Pathania, R. and Navani, N.K. (2012) Green Synthesis and Antimicrobial Potential of Silver Nanoparticles. International Journal of Green Nanotechnology .4(1), 1-16.
  • Bhatia, A., Ali, M., Jitendra, S., Madan, S., Pathania, R., Ahmed,N., Kazmi. A.A. (2012) Microbial diversity during rotary drum and windrow pile composting. Journal of Basic Microbiology .52, 5–15.
  • Bhatia, A., Madan, S., Jitendra, S., Ali, M., Pathania, R., Kazmi, A, A. (2012) Diversity of bacterial isolates during full scale rotary drum composting. Waste Management .33, 1595- 1601.
  • Pathania, R., Zlitni, S., Barker, C., Das, R., Gerritsma, D., Lebert, J., Awuah, E., Melacini, G., Capretta, F. and Brown, E. (2009) Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting. Nature Chemical Biology. 5, 849-856.
  • Mok, W., Navani, N.K., Barker,C., Sawchyn,B., Gu, J., Pathania, R.,  Zhu, R., Brown, E. and  Yingfu Li. (2009) Identification of a toxic peptide through bidirectional expression of small RNAs. Chembiochem .10, 238-241.
  • Pathania, R. and Brown, E.D (2008) Small and lethal: searching for new antibacterial compounds with novel modes of action. Biochemistry and Cell Biology .86(2)111-5.
  • Pathania, R., Navani,N.K., Rajmohan, G. and Dikshit, KL. (2002) Mycobacterium tuberculosis   hemoglobin HbO associates with membranes and stimulates cellular respiration of recombinant E.coli. Journal of Biological Chemistry .277(18), 15293-15302.
  • Pathania, R., Navani,N.K., Gardner, A.M., Gardner, P.M. and Dikshit, KL. (2002) Nitric oxide scavenging and detoxification by the Mycobacterium tuberculosis hemoglobin, HbN, in E. coli. Molecular Microbiology. 45(5):1303-14
  • Ramandeep, Pathania, R., Sharma, V., Mande, S.C., & Dikshit, K.L. (2002). Chimeric Vitreoscilla hemoglobin (VHb) carrying flavoreductase domain relieves nitrosative stress in E. coli: new insight into the functional role of VHb. Applied and Environmental Microbiology .68, 152-160.