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Barthwal, Ritu, (Mrs)
Ritu Barthwal Professor ritubfbs[at]iitr.ac.in 91-01332-285807
Areas of Interest
  • Molecular Biophysics, Structure, Conformation and Interactio of biomolecules by NMR/other techniques
Professional Background
FromToDesignationOrganisation
2017continuingEmeritus FellowDept. Biotechnology, IIT Roorkee
20092017Professor (HAG)Department of Biotechnology, IIT Roorkee
19962009ProfessorDepartment of Biotechnology, IIT Roorkee
19861996ReaderDepartment of Biotechnology, IIT Roorkee/University of Roorkee
19811986LecturerDepartment of Biotechnology, IIT Roorkee/University of Roorkee
19771981LecturerDepartment of Biophysics & Crystallography, University of Madras, Guindy Campus,Madras
19761977CSIR Scientists Pool OfficerSchool of Environmental Sciences, Jawahar Lal Nehru University, New Delhi
19841985Guest Scientist Abteilung Physiologische Chemie, RWTH Aachen University, Germany
19811981Post Doc FellowCentre Biophysique Moleculaire CNRS Orleans France
Honors and Awards
AwardInstituteYear
Most Inspiring Women Scientist/Engineer of IndiaIIT Roorkee2014
UGC National AssociateUniversity of Roorkee / Univ. of Madras1979-1984
National Science Talent Search Scholarship (NSTS). NCERT, Govt. of India1967-1976
Educational Details
DegreeSubjectUniversityYear
Ph.DPhysicsI.I.T.Delhi1976
M.Sc. Hons. SchoolPhysicsPanjab University Chandigarh1972
B.Sc. Hons. SchoolPhysicsPanjab University Chandigarh1971
Administrative Background
FromToDesignationOrganisationLevel
20082011Head of the DepartmentDept. Biotech. IIT Roorkee
19941997Head of the DepartmentDept. Biotech. IIT Roorkee
19881991Head of the DepartmentDept. Biotech. IIT Roorkee
20062016CoordinatorNMR Facilty (A Unit) , IIT Roorkee
20122016Chairman Institute Bio-Safety Committee IBSCIIT Roorkee
20122016Presiding Officer, Internal Complaints Committee ICC for Sexual Harassment of Women at Work PlaceIIT Roorkee
20022007Chief Vigilance Officer CVOIIT Roorkee
20132015Chairman Institute Purchase ComitteeIIT Roorkee
20112014• Chairman, Panel of Screening/Selection Committees, Sponsored Project StaffIIT Roorkee
19811984• Warden, Sarojini Bhawan (Girls Hostel)IIT Roorkee
Sponsored Research Projects
TopicFunding AgencyYear
Flavonoids and their interaction with a human telomeric G-quadruplex sequence for anticancer therapyDST2010
"NMR Structural and Biophysical Studies on ligand (anthraquinone derivatives)-G quadruplexesDept. Biotechnology DBT, Govt. of India2017
Search for therapeutic agents of herbal origin to target diabetes and cancerMinistry of Environment and Forests, Govt. of India, 2007
4. Molecular Modeling of drug-DNA complexesMHRD2004
Molecular modeling of drug-DNA complexesDAE-BRNS1999
Anticancer drug designing based on study of drug-DNA complexes by NMR spectroscopyCSIR1999
Design of anticancer drugs based on drug-DNA interactions and molecular modelingCDAC Pune2001
Unusual DNA structures, R& D in BiotechnologyAICTE1995
Nucleic acid interactions with specific oligo-peptides and drugsDST1988
Bio-molecular interactions An NMR, theoretical and spectroscopic investigations of DNA interactionDST1984
Participation in seminars
NamePlaceSponsored ByDate
2nd International Conference on Bioscience and Biotechnology 2017Colombo, Sri LankaUniv.Jayewardenepur and Univ KentMar 2017
19th SUNYA Conversation- Intl Conference on Biomolecular structure-conformationSUNY Albany USASUNY Albany USAJun 2015
9th Asian Biophysics Association SymposiumShangyu, Hangzhou, ChinaAsian Biphysical SocietyMay 2015
17th SUNYA Conversation- Intl Conference on Biomolecular structure-conformation,SUNY Albany USASUNY Albany USAJun 2013
7th Asian Biophysics Association SymposiumIndia Intl Centre New DelhiAsian Biophysical SocietyJan 2011
XXIV International Conference on Magnetic Resonance in Biological Systems Cairns AustraliaIntl Society Mag Res in Biol SystemsAug 2010
16th International Biophysics CongressLong Beach California USAIntl Union of Pure and Applied Biophysics IUPABFeb 2008
Bruker Avance 1D & 2D NMR and Maintenance CoursesFallanden SwitzerlandBruker Biospin SwitzerlandSep 2006
XXI International Conference on Magnetic Resonance in Biological SystemsHyderabad IndiaIntl Soc Mag Res in Biol Systems ICMRBSJan 2005
International Indo-Russian Workshop “High Performance Computing in Science and EngineeringMoscow RussiaDSt (ILTP)june 2003
XIII International Biophysics Congress New DelhiIntl Union of Pure and Applied biophysics IUPABSep 1999
XVIIIth International Conference on Magnetic Resonance in Biological Systems Tokyo, JapanIntl Soc Mag Res in Biol Systems ICMRBSAug 1998
XVII International Conference on Magnetic Resonance in Biological Systems Keystone, Colarado USAIntl Soc Mag Res in Biol Systems ICMRBSAug 1996
16th International Congress in Biochemistry and Molecular Biology New DelhiIntl Union of Biochemistry and Molecular Biology IUBMBSep 1994
XII International Conference on Magnetic Resonance in Biological Systems Todtmoos, GermanyIntl Soc Mag Res in Biol Systems ICMRBSSep 1986
6th Ampere International School on Nuclear Magnetic Resonance in BiologyLeibnitz, AustriaIntl Soc Mag Res in Biol Systems Sep 1981
International Conference on BiophysicsFort Aguada Beach Resort, Goa, IndiaTata Institute of Fundamental Research TIFR BombayDec 1980
Indo Italian Workshop on Magnetic Resonance (NMR and EPR)SG PGI LucknowSG Post Graduate Medical Instt Lucknow
Memberships
  • Indian Biphysical Society IBS, Life Member & Executive committee Member (2006-09)
  • Nuclear Magnetic Resonance (NMR) Society, India, Life Member & Executive CommitteeMember (2006-09)
  • DNA Socity of India, Life Member
PHDs Supervised
TopicScholar NameStatus of PHDRegistration Year
Interaction of anthracyclines with human telomeric G-quadruplex DNA Shailja RajeO2014
Structural and biophysical studies of interaction of anthracyclines with G-quadruplex DNAZia TariqO2013
NMR structural and biophysical studies on interaction of alkaloids with G-quadruplex DNAKumar Padma priyaO2011
Interaction of Flavonoids and Mitoxantrone with Tetrahymena G-quadruplex DNA sequencesTarikere Palakshan PradeepA2009
Interaction of Luteolin and Mitoxantrone with (Human) G-quadruplex DNA sequencesSweta TripathiA2009
Therapeutic potential of some herbs and structure of berberrubine-DNA complexSyed Asif HasanA2005
Interaction of Palmatine with DNA by spectroscopic and molecular modeling techniquesKushuma BishtA2004
Structural studies of berberine and berberrubine and their interaction with DNALata ChauhanA2004
Structural studies of Flavonoids and their interaction with duplex and quadruplex DNAAmit KumarA2004
Anthraquinone based anti cancer drug mitoxantrone and its complex with DNAR DurairajA2003
Drug-DNA interactions by spectroscopic and molecular modeling techniquesPrashansa AgrawalA2002
Structural studies of anticancer drug mitoxantrone and its complex with DNA Manpreet Kaur NarangA2001
Study of drug-DNA interactions by NMR spectroscopy MonicaA2000
Studies on development of membrane sensors and their analytical applicationsAnupamA1991
Studies on glycoprotein enzymes of peanut cotyledon cell membranes Anu GuptaA1991
Interaction of anticancerous drug daunomycin with nucleic acidsUma SharmaA1992
Interaction of anticancerous drugs with specific oligonucleotidesNandana SrivastavaA1992
Protein-nucleic acid interactions - Interaction of tyrosine containing model oligopeptides with someAnita AgrawalA1989
Protein-nucleic acid interactionsShrikant KukretiA1985
Drug-nucleic acid interactionsAnwer MujeebA1985
Courses or Conferences Organised
Conference NameSponsored ByDate
International Workshop on Educational and Capacity Building in Biophysics (ECBB)IUPAB, DST, CSIR, UGC, IIT RoorkeeFeb 2003
National Symposium in Biophysics (NSB)IUPAB, DST, CSIR, UGC, IIT RoorkeeFeb 2003
National International Collaboration
TopicOrganisationLevel
Drug-Nucleic Acid Interactions with research Group of Professor Girjesh GovilTata Institute of Fundamental research TIFR BombayRP
NMR Studies of Anti-cancer compounds with Research Group of Prof. N R JagannathanAll India Institute of Medical Sciences AIIMS, New DelhiRP
NMR based structure of Drug-DNA complexes with research group of Professor Surat KumarDayalbagh Educational Institute, AgraRP
Molecular Modeling in Drug-DNA Complexes with research group of Dr Pamita AwasthiNIT HamirpurRP
Refereed Journal Papers
  1. NMR based structural studies decipher stacking of the alkaloid coralyne to terminal guanines at two different sites in parallel G-quadruplex DNA, [d(TTGGGGT)]4 and [d(TTAGGGT)]4, Kumar Padmapriya and Ritu Barthwal. Biochimica et Biophysica Acta (BBA) - General Subjects, 1861, 37-48 (2017).
  1. Nuclear magnetic resonance studies reveal stabilization of parallel G-quadruplex DNA [d(T2G4T)]4 upon binding to protoberberine alkaloid coralyne, Kumar Padmapriya and Ritu Barthwal. Bioorganic and Medicinal Chemistry letters, 26, 4915-4918 (2016).
  1. Binding of the alkaloid coralyne to parallel G-quadruplex DNA [d(TTGGGGT)]4 studied by multi-spectroscopic   techniques, Kumar Padmapriya and Ritu Barthwal. Biophysical Chemistry, 219, 49-58 (2016) .
  1. Molecular recognition of parallel quadruplex d-(TTGGGGT)4 by mitoxantrone: binding with 1:4 stoichiometry leads to telomerase inhibition, Tarikere Palakshan Pradeep, Sweta Tripathi and Ritu Barthwal. (Royal Society of Chemistry) RSC Advances, 6, 71652-71666 (2016). 
  1. NMR structure of dual site binding of mitoxantrone dimer to opposite grooves of parallel stranded G-quadruplex d-(TTGGGGT)4, Tarikere Palakshan Pradeep and Ritu Barthwal. Biochimie, 128-129, 59-69 (2016).
  1. A 4:1 stoichiometric binding and stabilization of mitoxantrone-parallel stranded G-quadruplex complex established by spectroscopy techniques, Tarikere Palakshan Pradeep and Ritu Barthwal. J. Photochemistry & Photobiology B: Biology, 162, 106-114 (2016).
  1. Molecular recognition of parallel DNA quadruplex d-(TTAGGGT)4 by mitoxantrone: Binding with 1:2 stoichiometry leading to thermal stabilization and telomerase inhibition. Sweta Tripathi, Tarikere Palakshan Pradeep and Ritu Barthwal. Chem Bio Chem. 17, 554-560 (2016).
     
  2. Moon, Utkarsh Ravindra, Debabrata Sircar, Ritu Barthwal, Sukanta Kumar Sen, Till Beuerle, Ludger Beerhues, and Adinpunya Mitra. "Shoot cultures of Hoppea fastigiata (Griseb.) CB Clarke as potential source of neuroprotective xanthones." Journal of Natural Medicines (2015): 1-12. Online
     
  3. NMR based structure of anticancer drug mitoxantrone stacked with terminal base pair of DNA hexamer sequence d-(ATCGAT)2, Shilpa Dogra, Pamita Awasthi, Sweta Tripathi, T P Pradeep, Maya S Nair and Ritu Barthwal, J. Biomol. Struct. Dynamics, 32 (2014) 1164-1183.
     
  4. Multispectroscopic methods reveal different modes of interaction of anticancer drug mitoxantrone with Poly (dG-dC).Poly(dG-dC) and Poly(dA-dT).Poly(dA-dT), Pamita Awasthi, Shilpa Dogra, and Ritu Barthwal, J. Photochemistry & Photobiology B : Biology 127,  78-87 (2013).
     
  5. Interaction of anticancer drug Mitoxantrone with DNA hexamer sequence d-(CTCGAG)2 by Absorption, Fluorescence and Circular Dichroism Spectroscopy, Shilpa Dogra, Pamita Awasthi, Maya Nair and Ritu Barthwal, J. Photochemistry & Photobiology B : Biology 123, 48-54 (2013).
     
  6. Comparative Molecular Modeling Study of Binding of Mitoxantrone with d-(ATCGAT)2 and d-(CTCGAG)2  Hexamer DNA Sequences, Shilpa Dogra, Pamita Awasthi and Ritu  Barthwal, International Journal of Current Research and Review, Manuscript code IJCRRNOV1230, ISSN: 2231-2196 (Print), ISSN: 0975-5241(Online) 2013.
     
  7. Interaction of Mitoxantrone and its Analogs with Methylated and Non-methylated CpG Islands in Tetrameric DNA Sequences: A Molecular Modeling Study, Pamita Awasthi, Shilpa Dogra, Lalit K. Awasthi and Ritu Barthwal, International Journal of Drug Design and Discovery 4, 1056-1064 (2013).
     
  8.  A Qualitative and Quantitative Assay to Study DNA/Drug Interaction Based on Sequence Selective Inhibition of Restriction Endonucleases, Syed A Hassan, Lata Chauhan, Ritu Barthwal and Aparna Dixit,Tropical Journal of Pharmaceutical Research  11, 721-727 (2012).
     
  9. Aqueous Bark Extract of Cinnamomum Zeylanicum: A Potential Therapeutic Agent for Streptozotocin-Induced Type 1 Diabetes Mellitus (T1DM) Rats, Syed A Hassan, Ritu Barthwal, Maya S Nair and Syed S Haque, Tropical Journal of Pharmaceutical Research 11,  429-435 (2012).
     
  10. DNA Binding studies of Vinca Alkaloids : experimental and Computational Evidence, Prateek Pandya, Surendra P Gupta, Kumud Pandav, Ritu Barthwal, B. Jayaram and Surat Kumar,  Natural Product Communications, 7, No. 3, 305-309 (2012).
     
  11. Methylene Linker Assisted DNA Binding of Vinblastine and Simpler analogs: purine – Pyrimidine Specificity of Indole Derivatives, Surendra prakash Gupta, Kumud Pandav, prateek Pandya, G. Suresh Kumar, Ritu Barthwal and Surat Kumar, Chemistry and Biology Interface 1, No. 2,  297-309 (2011).
     
  12. Modeling of HIV-1 TAR RNA-Ligand Complexes. Mitrasinovic PM, Tomar JS, Nair MS, Barthwal R. Medicinal Chemistry 7, 301-308 (2011).
     
  13. Molecular modeling study of interaction of anthracenedione class of drug mitoxantrone and its analogs with DNA tetrameric sequences.  Pamita Awasthi , Shilpa Dogra , Lalit Kumar Awasthi, Ritu Barthwal Advances in Experimental Medicine and  Biology 696, 385-400 (2011) Chapter 39, Springer Verlag .
     
  14. Solution studies on the complex of 4’-epiadriamycin-d-(CGATCG)2 followed by time-resolved fluorescence measurement, diffusion ordered spectroscopy and restrained molecular dynamics simulations. Prashansa Agrawal, Sudhir Kumar Barthwal, Girjesh Govil and Ritu Barthwal Bioorganic & Medicinal Chemistry 17, 2793–2811 (2009).
     
  15. Studies on the complex of Adriamycin-d-(TGATCA)2 by Proton Nuclear Magnetic Resonance Spectroscopy, Time-resolved Fluorescence Measurement and Restrained Molecular Dynamics Simulations. Prashansa Agrawal, Sudhir Kumar Barthwal, Girjesh Govil and Ritu Barthwal. Journal of Molecular Structure 932, 67-83 (2009).
     
  16. Studies on Self-aggregation of Anthracycline Drugs by Restrained Molecular Dynamics approach using Nuclear Magnetic Resonance Spectroscopy supported by Absorption, Fluorescence, Diffusion Ordered Spectroscopy and Mass Spectrometry. Prashansa Agrawal, Sudhir Kumar Barthwal and Ritu Barthwal. European Journal of Medicinal Chemistry, 44, 1437-1451 (2009).
     
  17. Studies on drug-DNA complexes adriamycin – d (TGATCA)2 and 4’-epiadriamycin-d-(CGATCG)2 by phopsphorus-31 nuclear magnetic resonance spectroscopy. Prashansa Agrawal, Girjesh Govil and Ritu Barthwal. Magnetic Resonance in Chemistry, 47, 390–397 (2009).
     
  18. Structural elucidation of 4’-epiadriamycin by nuclear magnetic resonance spectroscopy and comparison with adriamycin and daunomycin using quantum mechanical and restrained molecular dynamics. Ritu Barthwal, Prashansa Agrawal, A.N. Tripathi, Uma Sharma, N.R. Jagannathan and Girjesh Govil. Archives of Biochemistry and Biophysics, 474, 48-64 (2008).
     
  19. Quantum chemical and nuclear magnetic resonance spectral studies on molecular properties and electronic structure of palmatine molecule. A.N. Tripathi, Kushuma Bisht, P.P. Thankanchan and Ritu Barthwal. Journal of Molecular Structure, 878, 139-148 (2008).
     
  20. Quantum chemical and nuclear magnetic resonance spectral studies on molecular properties and electronic structure of berberine and berberrubine. A.N. Tripathi, Lata Chauhan, P.P. Thankanchan and Ritu Barthwal. Magnetic Resonance in Chemistry 45, 647-655 (2007).
     
  21. Structure of daunomycin complexed to deoxyhexanucleotide d-TGATCA by two dimensional nuclear magnetic resonance spectroscopy. Ritu Barthwal, Uma Sharma, Nandana Srivastava, Monica, Pamita Awasthi, Manpreet Kaur, S.K. Barthwal and Girjesh Govil, European Journal of Medicinal Chemistry  41, 27-39 ( 2006).
     
  22. Restrained molecular dynamics study of adriamycin complexed to deoxyhexanucleotide d-CGATCG. Monica, S. K. Barthwal, Ritu Barthwal and Girjesh Govil, Archives of Biochemistry & Biophysics 439, 12-24 (2005).
     
  23. Structure of DNA hexamer sequence d-TGATCA by two dimensional nuclear magnetic resonance spectroscopy and restrained molecular dynamics. Ritu Barthwal, Pamita Awasthi,, Monica, Uma Sharma, , Nandana Srivastava, Manpreet Kaur, S.K. Barthwal and Girjesh Govil, Journal of Structural Biology 148, 34-50 (2004).
     
  24. Structure of DNA hexamer sequence d-CGATCG by two dimensional nuclear magnetic resonance spectroscopy and restrained molecular dynamics. Ritu Barthwal, Monica, Pamita Awasthi,, Nandana Srivastava, Uma Sharma, Manpreet Kaur and Girjesh Govil, Journal of Biomolecular Structure & Dynamics 21, 817-839 (2003).
     
  25. A 500 MHz proton NMR study of interaction of tetrapeptide Lys-Trp-Gly-Lys OtBu and tripeptide Lys-Tyr-Lys with deoxy dinucleotide d-GpC. Ritu Barthwal, Shrikant Kukreti, Anwer Mujeeb and Girjesh Govil, Quart. Magnetic Resonance in Biology and Medicine 3, 225-238 (1995).
     
  26. A proton nuclear magnetic resonance investigation of the conformation of daunomycin. Ritu Barthwal, Anwer Mujeeb, Nandana Srivastava and Uma Sharma, Chemico-Biol. Interactions 100, 125-139 (1995).
     
  27. A 500 MHz proton NMR study of conformation of Adriamycin. Ritu Barthwal, Nandana Srivastava, Uma Sharma and Girjesh Govil, Journal of Molecular Structure 327, 201-220 (1994).
     
  28. A 500 MHz proton NMR studies of interaction of tetrapeptide Lys?Trp?Gly?Lys OtBu with deoxy dinucleotide d?CpG. Ritu Barthwal, Girjesh Govil, Satish Kumar Singh, Shrikant Kukreti and Anwer Mujeeb, Quart. Magnetic Resonance in Biology and Medicine 1, 17-22 (1994).
     
  29. Interaction of daunomycin with deoxydinucleotide d?CpG by two dimensional NMR techniques. Ritu Barthwal, Anwer Mujeeb and Girjesh Govil, Archives of Biochemistry & Biophysics 313, 189-205 (1994).
     
  30. Theoretical studies on intercalation of actinomycin between base pairs of dinucleotide model systems. Ritu Barthwal, Anwer Mujeeb, and Girjesh Govil, Journal of Indian Chemical Society 70, 929-938 (1993).
     
  31.  A 500 MHz proton NMR study of binding of the tripeptide Lys?Tyr?Lys with tetradeoxynucleotides d?CpCpGpG and d-CpGpCpG, Ritu Barthwal, Shrikant Kukreti, Anwer Mujeeb and Girjesh Govil, MAGMA 1, 145-157 (1993).
     
  32. A 500 MHz proton NMR study of binding of tripeptide Lys?Tyr?Lys with deoxy dinucleotide d?CpG. Ritu Barthwal, Shrikant Kukreti and Anwer Mujeeb, Indian Journal of Biochemistry & Biophysics 29, 394?401 (1992).
     
  33. A 500 MHz proton NMR study of stacking interactions: Binding of tripeptide Lys?Tyr?Lys to tetradeoxynucleotide d?GpCpGpC. R. Barthwal, A. Mujeeb, S. Kukreti, A. Gupta and G. Govil, Journal of Molecular Recognition 4, 45?52 (1991).
     
  34. One dimensional and two dimensional proton NMR studies on actinomycin D. Anwer Mujeeb and Ritu Barthwal, Intl. Journal of Magnetic. Resonance in Biology and Medicine 1, 1?7 (1991).
     
  35. Proton magnetic resonance studies of the binding of oligopeptides containing tryptophan to polyribonucleotides Poly A, Poly U and Poly C. Ritu Barthwal, Gerard Lancelot, Anjna Agarwal, Anwer Mujeeb and Shrikant Kukreti, Physiol. Chem. Phys. & Medical NMR 20, 145?159 (1988).
     
  36. Interaction of tryptophan containing oligopeptides with d?CGCG by proton NMR. Ritu Barthwal, Anjna Agarwal, Shrikant Kukreti and Anwer Mujeeb, Physiol. Chem. Phys. & Medical NMR 19, 125?139 (1987).
     
  37. In vitro proton T1 and T2 studies on rat liver: Analysis of multi exponential relaxation processes. R.Barthwal, M.Hohn-Berlage and K.Gersonde, Magnetic Resonance in Medicine 3, 863-875 (!986)