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Prabhat Kumar Mandal
Prabhat Kumar Mandal Assistant Professor pkm31fbt[at]iitr.ac.in 91-1332-284780
Areas of Interest
  • Human Genetics, Genomics, Proteomics, Next generation sequencing, RNAi, Jumping genes in health and disease.
Educational Details
DegreeSubjectUniversityYear
B.ScPhysiologyCalcutta University, West Bengal, India1997
M.Sc.Biophysics and Molecular BiologyCalcutta University, West Bengal, India1999
Ph.D.Molecular ParasitologyJawaharlal Nehru University, New Delhi, India2006
Postdoctoral FellowHuman Genetics Dept. of Genetics,University of Pennsylvania (USA) 2006-2010
Postdoctoral FellowHuman GeneticsJohns Hopkins University (USA)2010-2013
Books Authored

1. H.H. Kazazian, Jr., M.d.c. Seleme, D.V.Babushok, D.M. Ostertag, M.R. Vetter, P.K. Mandal. Human diversity and L1 Retrotransposons Biology: Creation of New Genes and Individual Variation in Retrotransposition Potential. Retrotransposition, Diversity and the Brain. Book Chapter, Pages 43-52.

 

Refereed Journal Papers

1. Sur D, Kustwar RK, Budania S, Mahadevan A, Hancks DC, Yadav V, Shankar SK, Mandal PK*. Detection of the LINE-1 retrotransposon RNA-binding protein ORF1p in different anatomical regions of the human brain. Mob DNA. 2017, 8:17. doi: 10.1186/s13100-017-0101-4. (Impact Factor-4.2).

2. Kumar R, Yadav A, Ratnam A, Kumar S, Bala M, Sur D, Narang S, Singh UP, Mandal PK*, Ghosh K*. Organometallic ruthenium nitrosyl obtained by C-H bond activation: Photoinduced delivery of nitric oxide (NO) and NO-mediated anti-proliferation activity studies. European Journal of Inorganic Chemistry, 2017.DOI: 10.1002/ejic.201700839.

3. Mandal PK, Kazazian HH Jr. Purification of L1-Ribonucleoprotein Particles (L1-RNPs) from Cultured Human Cells. Methods Mol Biol (Springer). 2016;1400:299-310.

4. Mandal PK, Ewing AE, Hancks DC, Kazazian HH Jr.  Enrichment of processed pseudogene transcripts in L1- ribonucleoprotein particles. Human Molecular Genetics. 2013. 22. 3730-3748. (Impact Factor-7.9).

5. Hancks DC, Mandal PK, Cheung LE, Kazazian HH Jr. The minimal active human SVA retrotransposon requires Only the 5'-hexamer and Alu-like domains. Molecular and Cellular Biology. 2012.32:4718-4726. (Impact Factor-5.8)

6. Yadav VP, Mandal PK, Bhattacharya A, Bhattacharya SSINE chimeras are formed at high frequency during induced retrotransposition in vivoNature communications. 2012 DOI:10.1038. (Impact Factor-10.01)

7. Hancks DC, Goodier JL*, Mandal PK*, Cheung LE, Kazazian HH Jr. Retrotransposition of marked SVA elements by human L1s in cultured cells. Human Molecular Genetics. 2011.20:3386-3400. (*Equal Contribution) (Impact Factor-7.9)

8. Goodier JL, Mandal PK, Zhang L, Kazazian HH Jr. Discrete subcellular partitioning of human retrotransposon RNAs despite a common mechanism of genome insertion. Human Molecular Genetics. 2010.19: 1712-1725. (Impact Factor-7.9)

9. Yadav VP, Mandal PK, Rao DN, Bhattacharya S. Characterization of the restriction enzyme-like endonuclease encoded by the Entamoeba histolytica non-long terminal repeat retrotransposon EhLINE1. FEBS J. 2009.276:7070-7082. (Impact Factor-4.0)

10. Mandal PK, Kazazian HH Jr. Snapshot: Vertebrate Transposons. Cell. 2008.135: 192. (Impact Factor- 35.0

11. Babushok DV, Ohshima K, Ostertag EM, Chen X, Wang Y, Mandal PK, Okada N, Abrams CS,  Kazazian HH Jr, A novel testis ubiquitin binding protein, S5a-like, arose by exon-shuffling in hominoids. Genome Research. 2007.17: 1129-1138. (Impact Factor-14.53)

12. Mandal PK, Rawal K, Ramaswamy R, Bhattacharya A, Bhattacharya S. Identification of insertion hot spots for non-LTR retrotransposons: computational and biochemical application to Entamoeba histolytica. Nucleic Acids Research. 2006.34: 5752-5763. (Impact Factor-8.2)

13. Mandal PK, Bagchi A, Bhattacharya A, Bhattacharya S. An Entamoeba histolytica LINE/SINE pair inserts at common target sites cleaved by the restriction enzyme-like LINE-encoded endonuclease. Eukaryotic Cell. 2004, 3:170-179. (Impact Factor-3.8)