Departmental Facilities
Research Scholars
Major Research Areas
Ongoing Projects
Pranita P. Sarangi
Pranita P. Sarangi Assistant Professor psarafbt[at] +91-1332-284788
Areas of Interest
  • Inflammation and cancer biology, sepsis, Cell-matrix interaction, cell migration, Immunomodulatory therapeutics, Cancer immunoediting
Professional Background
2014presentAssistant ProfessorIIT Roorkee
2013PresentSpecial Research VolunteerNational Institute of Health/NIDCR
2011presentResearch FellowNational Institutes of Health/NIDCR, USA
20082011Postdoctoral Research AssociateSchool of Medicine and Dentistry, University of Rochester, USA
20032008Research AssistantUniversity of Tennessee, Knoxville, USA
20032003Junior Veterinary OfficerDept of Fisheries and Animal Husbandry, Govt of Odisha
20022003Veterinary Extension OfficerHeifer International/India
Educational Details
PhDComparative and Experimental MedicineUniversity of Tennessee, Knoxville, USA2008
Bachelor in Veterinary Science Veterinary ScienceO.U.A.T, Bhubaneswar, India2002
Administrative Background
2017presentFaculty Advisor, NCC and NSSIIT Roorkee
2015present NCC Officer3 UK CTR IITR
2014presentIn Charge - Experimental Animal FacilityIIT Roorkee
2016PresentMember, Dept Academic Program CommitteeIIT Roorkee
Sponsored Research Projects
TopicFunding AgencyYear
Cell-matrix interraction in inflammation and sepsisDBT, Govt. of India2014
Immunomodulatory effect of adhesion protein Fibulin7 (Fbln7) on immune cell activation and functionDST, Govt. of India2015
Books Authored
  1. Sarangi PP, Rouse BT. Herpetic Keratitis. 2009. Levin and Albert Ocular Disease: Mechanisms and Management, Chapter 12, Elsevier, 


Refereed Journal Papers


  1. *Sarangi PP, Chakraborty P, Dash SP, Ambatipudi K, Vega SD, Ikeuchi T, Wahl L, *Yamada Y. Cell adhesion protein Fibulin-7 and its C-terminal fragment negatively regulate monocyte and macrophage migration and functions in vitro and in vivo. *Corresponding authors (Under Revision)


  1. Sarangi PP, Lee H, Lerman Y, Harrower E., Rezaie AR, Kim M. 2017. Activated protein C attenuates severe inflammation by selectively targeting VLA-3high neutrophil subpopulation in mice Journal of Immunology. Sept 6 (Ahead of print)


  1. Lerman YV, Lim K, Hyun YM, Falkner LK, Sonnenberg A, Lacy-Hulbert A, Pietropaoli A, *Sarangi PP, *Kim M. 2014.Sepsis lethality through exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils isdependent on integrin a3b1Blood Dec;124 (24) *Co-Corresponding author. Received special commentary by Mitrouli et al in the same issue of Blood.


  1. *Sarangi PP, Hyun YM, Lerman Y LermanV, Pietropaoli A, *Kim M. 2012. Essential Role of integrin β1 in tissue homing of neutrophils during sepsis. Shock. Aug;38(3):281-7*Co-Corresponding author


  1. Hyun, YM, Ronen Sumagin, Sarangi PP, Elena Lomakina E, Overstreet MG, Baker C, Fowell DJ, Waugh R, Sarelius IG, Kim M. 2012. Uropod Elongation is a common final step in leukocyte extravasation from inflamed vessels. Journal of Experimental Medicine. Jul 2;209(7):1349-62


  1. *Elphick GF, *Sarangi PP, Hyun Y, Hollenbaugh JA, Ayala A, Biffl WL, Chung H, Rezaie AR, McGrath JL, Topham DJ, Reichner JS, Kim M. 2009. Recombinant human activated protein C inhibits integrin-mediated neutrophil migration. Blood. 113(17):4078-85 *Co-First Author. Cited in Nature’s Scibx Journal


  1. Sarangi PP, Woo SR, Rouse BT. 2009. Modulation of herpes virus induced ocular immunopathology by anti-CD200R:Fc treatment. Clinical Immunology. 131(1):31-40


  1. Sarangi PP, Kim B, Rouse BT. 2008. Modulation of herpes virus induced ocular immunopathology by non-mitogenic anti-CD3 monoclonal antibody treatment. Investigative Ophthalmology & Visual Science. 49(12):5425-33


  1. Sarangi PP, Sehrawat S, Suvas S, Rouse BT. 2008. IL-10 and natural regulatory T cells: Two independent anti-inflammatory mechanisms in HSV induced ocular immunopathology. Journal of Immunology. 180(9):6297-306


  1. Sehrawat S, Suvas S, Sarangi PP, Shuryawanshi A, Rouse BT. 2008. In vitro generated antigen specific CD4+CD25+Foxp3+ regulatory T cells control the severity of virus induced immunoinflammatory lesion. Journal of Virology. 82(14):6838-51


  1. *Kim B, *Sarangi PP, Ahmet Kursat Azkur, Deshpande Kaistha S, Rouse BT. 2008. Enhanced viral immunoinflammatory lesions in mice lacking IL-23 responses.Microbes and infections. 10(3):302-312 * Co-First Author.


  1. Sarangi PP, Kim B., Kurt-Jones E, Rouse BT. 2007. Innate recognition network driving the HSV induced corneal immunopathology: Role of Toll Pathway in the early inflammatory events in Stromal Keratitis. Journal of Virology. 81(20):11128-38??


  1. Kim B, Sarangi PP, Y Lee Deshpande Kaistha S, Lee S, Rouse BT. 2006. Depletion of MCP-1 increases development of herpetic stromal keratitis by innate immune modulation. Journal of Leukocyte Biology. 80(6):1405-15 Recommended in Faculty1000


  1. Kim B, Suvas S, Sarangi PP, Lee S, Reisfield RA, Rouse BT. 2006. Vascular endothelial growth factor receptor2-based DNA immunization delays development of herpetic stromal keratitis by antiangiogenic effects. Journal of Immunology. 177(6):4122-31


  1. Suvas S, Kim B, Sarangi PP, Tone M, Waldmann, H, Rouse BT. 2005. In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology. Journal of Virology. 79(18):11935-42


Invited Reviews

  1. Rouse BT, Sarangi PP, Suvas S. 2006. Regulatory T cells in virus infections.    Immunological Reviews. 212:272-86


  1. Sarangi PP, Lee Hyun-wook and Kim M. 2010. Activated Protein C action in inflammation. British Journal of Hematology. 148(6):817-33 


  1. Bhan C, Dipankar P, Chakraborty P, Sarangi PP*. 2016. Role of Cellular Events in the Pathophysiology of Sepsis. Inflammation Reserach. 65 (11), 853-868