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P Gopinath
P. Gopinath Associate Professor pgopifnt[at]iitr.ac.in 01332285650 Website
Areas of Interest
  • Cancer nanotechnology, Drug delivery, Biomaterials, Bioimaging , Tissue engineering, Environmental nanotechnology
Professional Background
FromToDesignationOrganisation
29.04.2016-till dateAssociate ProfessorIIT Roorkee, Roorkee, Uttarakhand.
06.06.201128.04.2016Assistant ProfessorIIT Roorkee, Roorkee, Uttarakhand.
23.09.201013.05.2011Assistant ProfessorAmrita University Coimbatore, Tamil Nadu.
20.10.200802.06.2010Post-Doctoral Research AssociateUniversity of Rochester Medical Center, Rochester, New York, USA.
04.01.200814.09.2008Senior Research FellowIIT Guwahati Department of Biotechnology, Guwahati, Assam
Educational Details
DegreeSubjectUniversityYear
Ph.D.BiotechnologyIndian Institute of Technology (IIT) Guwahati2008
M.Sc.Biotechnology Srimad Andavan Arts and Science College, Bharathidasan University, Trichy2003
B.Sc.Microbiology Srimad Andavan Arts and Science College, Bharathidasan University, Trichy2001
Administrative Background
FromToDesignationOrganisationLevel
26.04.2017-till dateAssociate Dean of Academic affairs (Admission)IIT Roorkee
17.02.2017-till dateAdvisory Committee member for TIEDS Incubation Centre- Dept. of Biotech.IIT Roorkee
Feb 2017-till dateMember in Sponsored Research & Industrial Consultancy Committee (SRICC)-Centre for Nanotechnology IIT Roorkee
March 2016-till dateMember in Institute Research Committee (IRC)- Dept. of BiotechnologyIIT Roorkee
May 2015-till dateInstitute bio-safety committee –Member IIT Roorkee
July 2011April 2015Faculty-in-charge for Training & Placement –Centre for Nanotechnology IIT Roorkee
April 2012June 2014Member in the Board of Research–Centre for Nanotechnology IIT Roorkee
01.07.201230.06.2014Member in the Institute Academic Programme Committee (IAPC)–Centre for Nanotechnology IIT Roorkee
Memberships
  • American Chemical Society (ACS), USA , Member
  • Royal Society of Chemistry, UK , Member
  • Indian Nanoscience society , Life member
  • Society for Biomaterials and Artificial Organs , Life member
  • Society for Tissue Engineering and Regenerative Medicine , Life member
  • Indian Science Congress Association , Life member
  • Indian society of chemists and Biologists , Life member
PHDs Supervised
TopicScholar NameStatus of PHDRegistration Year
Development of albumin based nanoparticles for biomedical applicationsBharat BhushanA2011
Silver nanoparticle and graphene oxide based nanocomposites for biomedical applicationsPoornima DubeyA2010
Development of carbon dots based multifunctional nanomaterials for potential applicationsAbhay SachdevA2013
Poly(amidoamine) dendrimer based nanomaterials for delivery of anticancer agentsIshita MataiA2013
Development of biofunctional polymeric nanofibers and their therapeutic implicationsS. Uday KumarA2012
Metal oxide nanostructures for potential applications in water remediationDeepika MalwalA2014
Special Lectures Delivered
TitlePlaceDate
Nano-remediation: Applications of nanotechnology for water purificationNIT Tiruchirappalli13.06.2016
Nanotoxicology : Cytotoxic and Genotoxic Potential of NanomaterialsNIT Tiruchirappalli13.06.2016
Cancer Nanotechnology: Applications of Nanomaterials for Cancer Diagnosis and Therapy SASTRA University13.02.2015
Nanomedicinal Properties of Silver NanoparticlesAnnamalai University09.01.2012
Promising Nanoscale Approaches for Cancer Diagnosis and Therapy IFTM University05.11.2016
Books Authored

Books

Book chapters

  • Vinay Kumar, P. Gopinath*, Vinoth-Kumar Lakshmanan, K. Navaneetha Pandiyaraj, ‘Surface analysis technique for assessing hemocompatibility of biomaterials’ in book titled “Hemocompatibility of Biomaterials for Clinical Applications” Elsevier. ISBN: 9780081004975 (2017) in press

  • M.C.Ramkumar, Pieter Cools,  A.Arunkumar,  Nathalie De Geyter,  Rino Morent, Vinay kumar, S.Udaykumar, P.Gopinath,  K.Navaneetha Pandiyaraj, ‘Polymer coatings for biocompatibility and reduced non-specific adsorption’ in book titled “Hemocompatibility of Biomaterials for Clinical Applications” Elsevier. ISBN: 9780081004975 (2017) in press

  • S.Raj Kumar and P. Gopinath*, ‘Nano-Bioremediation: Applications of Nanotechnology for Bioremediation’ in book titled “Remediation of Heavy Metals in the Environment” CRC Press (2016) 27–48.

  • A. Sachdev, S. Uday Kumar, I. Matai, G. Bhargavi, P. Dubey, B. Bhushan and P.Gopinath*. ‘Polymers as nanocarrier for cancer theranostic applications’ in book titled “Recent Developments in Carbohydrates Polymer Research” Research Signpost Publishers (2014) chapter 4, page no. 45-55, ISBN: 978-81-308-0534-4

  • I. Matai, A. Sachdev, S. Uday Kumar, P. Dubey, B. Bhushan and P.Gopinath* ‘Dendrimer: A promising nanocarrier for cancer therapy’ in book titled “Nanotechnology: Recent Trends, Emerging Issues and Future Directions” Nova publishers (2014) chapter 7, page no. 127-155, ISBN 978-1-63117-561-9.

Refereed Journal Papers
  1. S.Raj Kumar, S. Mohiyuddin, P.Gopinath*. Electrospun Polyacrylonitrile (PAN) templated 2D nanofibrous mats: A platform towards practical applications for the dye removal and bacterial disinfection. ACS Omega. 2017 (in press)

  2. S. Naqvi, S. Mohiyuddin, P.Gopinath*.Niclosamide loaded biodegradable chitosan nanocargoes: an in vitro study for the potential application in cancer therapy. Royal Society Open Science. 2017 (in press)

  3. M.C.Ramkumar, K.N. Pandiyaraj, A.Arun Kumar, P.V.A.Padmanabhan, P. Cools, N. De Geyter, R. Morent, S.Uday Kumar, Vinay Kumar, P.Gopinath, S. K.Jaganathan, R.R. Deshmukh. Atmospheric pressure non-thermal plasma assisted polymerization of poly (ethylene glycol) methylether methacrylate (PEGMA) on low density polyethylene (LDPE) films for enhancement of biocompatibility. Surface and Coatings Technology, 2017 (in press)

  4. A.Saini, K. R.Justin Thomas, A. Sachdev and P.Gopinath. Photophysics, electrochemistry, morphology and bioimaging applications of new 1,8-naphthalimide derivatives containing different chromophores, Chemistry – An Asian Journal2017 (in press)

  5. S. Aiswarya Devi, M. Harshiny, S.Uday Kumar, P.Gopinath, M.Matheswaran. Strategy of metal iron doping and green mediated ZnO nanoparticles: dissolubility, antimicrobial and cytotoxic traits, Toxicology Research2017 (in press)

  6. S.Uday Kumar, B. Bhushan, and P.Gopinath*. Bioactive carbon dots lights up microtubules and destabilises cell cytoskeletal framework - a robust imaging agent with therapeutic activity. Colloids and Surfaces B: Biointerfaces, 2017 (in press).

  7. Bharat Bhushan, Vitaly Khanadeev, Boris Khlebtsov, Nikolai Khlebtsov and P. Gopinath*. Impact of albumin based approaches in nanomedicine: Imaging, targeting and drug delivery. Advances in Colloid and Interface Science, 2017,246, 13-39.

  8. K.Navaneetha Pandiyaraj, A.Arun Kumar, M.C.RamKumar, S.Uday Kumar, P.Gopinath, Pieter Cools, N. De Geyter, R. Morent, M. Bah, S. Ismat Shah, Pi-Guey Su, R.R. Deshmukh. Effect of processing parameters on the deposition of SiOx-like coatings on the surface of polypropylene films using glow discharge plasma assisted polymerization for tissue engineering applications. Vacuum, 2017,143, 412-422.

  9. D. Malwal and P. Gopinath*. Silica stabilized magnetic-chitosan beads for removal of arsenic from water. Colloid and Interface Science Communications, 2017, 19, 14-19

  10. D. Malwal and P. Gopinath*.CuO-ZnO nanosheets with p–n heterojunction for enhanced visible light mediated photocatalytic activity. ChemistrySelect, 2017, 2, 4866–4873

  11. B. Tirkey, B. Bhushan, S.Uday Kumar and P.Gopinath*. Prodrug encapsulated albumin nanoparticles as an alternative approach to manifest anti-proliferative effects of suicide gene therapy. Materials Science & Engineering C, 2017, 73, 507–515

  12. Sauraj, S.Uday Kumar, P.Gopinath, Y.S. Negi. Synthesis and bio-evaluation of xylan-5-fluorouracil-1-acetic acid conjugates as prodrugs for colon cancer treatment. Carbohydrate Polymers, 2017, 157,1442–1450 

  13. N. Singh, A. Sachdev and P. Gopinath*, Polysaccharide functionalized single walled carbon nanotubes as nanocarriers for delivery of curcumin in lung cancer cells. Journal of Nanoscience and Nanotechnology, 2017, (in press) 

  14. N. Pal, P.Dubey, P.Gopinath, K. Pal. Combined effect of cellulose nanocrystal and reduced graphene oxide into poly-lactic acid matrix nanocomposite as a scaffold and its anti-bacterial activity. International Journal of Biological Macromolecules, 2017, 95, 94–105

  15. S.Raj Kumar and P. Gopinath*, In situ synthesis of chitosan coated silver-zinc oxide nanocomposites and its enhanced antibacterial properties. Journal of Nanoscience and Nanotechnology, 2017, 17, 1–9 

  16. D. Malwal and P.Gopinath*. Efficient adsorption and antibacterial properties of electrospun CuO-ZnO composite nanofibers for water remediation. Journal of Hazardous Materials, 2017, 321, 611–621 

  17. D. Malwal and P. Gopinath*, Rapid and efficient removal of arsenic from water using electrospun CuO-ZnO composite nanofibers.RSC Advances, 2016, 6, 115021-115028

  18. S.Raj Kumar and P. Gopinath*, Dual applications of silver nanoparticles incorporated functionalized MWCNTs grafted surface modified PAN nanofibrous membrane for water purification. RSC Advances, 2016, 6, 109241 - 109252

  19. P.Dubey and P.Gopinath*. Functionalized Graphene Oxide based Nanocarrier for Tumor-Targeted Combination Therapy to Elicit Enhanced Cytotoxicity against Breast Cancer cells in vitro. ChemistrySelect, 2016, 1, 4845 – 4855.

  20. P.Dubey and P.Gopinath*. PEGylated Graphene Oxide based Nanocomposite grafted Chitosan/Polyvinyl alcohol Nanofiber as an Advanced Antibacterial Wound Dressing. RSC Advances, 2016, 6, 69103-69116

  21. B.Bhushan, S.Nandhagopal, R.Rajesh Kannan and P.Gopinath*. Therapeutic Nanozyme: Antioxidative and cytoprotective effects of nanoceria against hydrogen peroxide induced oxidative stress in fibroblast cells and in zebrafish. ChemistrySelect, 2016, 1, 2849 – 2856

  22. B. Bhushan, S.Uday Kumar and P.Gopinath*. Multifunctional carbon dots as efficient fluorescent nanotags for tracking cells through successive generations. Journal of Materials Chemistry B, 2016, 4, 4862-4871  

  23. B.Bhushan,S.Nandhagopal, R.Rajesh Kannan and P.Gopinath*. Biomimetic nanomaterials: Development of protein coated nanoceria as a potential antioxidative nano-agent for the effective scavenging of reactive oxygen species in vitro and in zebrafish model. Colloids and Surfaces B: Biointerfaces, 2016, 146, 375–386

  24. S. Uday Kumar and P.Gopinath*. Field-actuated Antineoplastic Potential of Smart and Versatile PEO-bPEI Electrospun Scaffold by Multi-staged Targeted Co-delivery of Magnetite Nanoparticles and Niclosamide-bPEI Complexes. RSC Advances, 2016,6,46186-46201

  25. K.Navaneetha Pandiyaraj, P.V.A.Padmanabhan, A.Arun, M.C.RamKumar, R.R.Deshmukh, Avi Bendavid, Pi-G Su, A.Sachdev, P.Gopinath. Cold atmospheric pressure (CAP) plasma assisted tailoring of LDPE film surfaces for enhancement of adhesive and cytocompatible properties: Influence of operating parameters. Vacuum, 2016, 130,34-47

  26. P.Dubey and P.Gopinath*. Nanocarriers for AKT siRNA based gene therapy. Austin Journal of Biotechnology & Bioengineering. 2016, 3(2), 1061 Editorial

  27. S. Uday Kumar and P.Gopinath*. Nanotechnology- A Promising Approach for Suicide Gene Therapy. Austin Journal of Nanomedicine & Nanotechnology. 2016, 4(1),1042. Editorial

  28. B.Bhushan and P.Gopinath*. Nano-Enabled Approaches for Lung Cancer Therapy. Austin Journal of Lung Cancer Research. 2016, 1(2), 1008. Editorial

  29. K.Navaneetha Pandiyaraj, A. Arun Kumar M.C.Ram Kumar, R.R.Deshmukh, Avi Bendavid , Pi-Guey Su, S.Uday Kumar, P.Gopinath. Effect of cold atmospheric pressure plasma gas composition on the surface and cyto-compatible properties of low density polyethylene (LDPE) film. Current Applied Physics, 2016, 16,784-792

  30. D. Malwal and P.Gopinath*. Enhanced photocatalytic activity of hierarchical three dimensional metal oxide@CuO nanostructures towards the degradation of Congo red dye under solar radiations. Catalysis Science & Technology , 2016,6, 4458-4472

  31. I. Matai and P.Gopinath*. Hydrophobic Myristic acid Modified PAMAM Dendrimers Augments the Delivery of Tamoxifen to Breast Cancer Cells. RSC Advances, 2016, 6,24808-24819

  32. K.N.Pandiyaraj, A.Arun Kumar, M.C.Ramkumar, A.Sachdev, P.Gopinath, Pieter Cools, N. De Geyter, R. Morent, R.R.Deshmukh, M.N. Nadagouda. Influence of non-thermal TiCl4/Ar+O2 plasma-assisted TiOx based coatings on the surface of polypropylene (PP) films for the tailoring of surface properties and cytocompatibility. Materials Science and Engineering C, 2016, 62, 908–918

  33. A. Sachdev, I. Matai and P.Gopinath*. Carbon Dots Incorporated Polymeric Hydrogels as Multifunctional Platform for Imaging and Induction of Apoptosis in Lung Cancer Cells. Colloids and Surfaces B: Biointerfaces, 2016, 141, 242–252 featured in ATLAS of Science

  34. A. Sachdev and P.Gopinath*. Monitoring the Intracellular Distribution and ROS Scavenging Potential of Carbon dots-Cerium oxide Nanocomposites in Fibroblast Cells. ChemNanoMat, 2016,2, 226–235

  35. I. Matai and P.Gopinath*. Chemically Crosslinked Hybrid Nanogels of Alginate and PAMAM Dendrimers as Efficient Anticancer Drug Delivery Vehicles. ACS Biomaterials Science & Engineering2016, 2,213–223

  36. P. Dubey and P.Gopinath*.Fabrication of electrospun poly (ethylene oxide)-poly (capro lactone) composite nanofibers for co-delivery of niclosamide and silver nanoparticles exhibits enhanced anti-cancer effects in vitro. Journal of Materials Chemistry B, 2016, 4, 726-742

  37. D. Malwal and P.Gopinath*. Fabrication and Applications of Ceramic nanofibers in Water Remediation: A review. Critical Reviews in Environmental Science and Technology, 2016,46, 500-534

  38. R. Manoj Kumar, K. K. Kuntal, S. Singh, P. Gupta, B. Bhushan, P. Gopinath and D. Lahiri. Electrophoretic deposition of hydroxyapatite coating on Mg–3Zn alloy for orthopaedic application. Surface and Coatings Technology, 2016,287,82–92

  39. S. Nayak, B. Bhushan, R. Jayaganthan, P. Gopinath, R.D. Agarwal and D.Lahiri. Strengthening of Mg based Alloy through Grain Refinement for Orthopedic Application. Journal of the Mechanical Behavior of Biomedical Materials,2016,59,57–70

  40. B. Bhushan and P.Gopinath*. Tumor-targeted folate-decorated albumin stabilised silver nanoparticle induce apoptosis at low concentration in human breast cancer cells. RSC Advances, 2015,5,86242-86253

  41. S. Uday Kumar and P.Gopinath*. Bioactive core-shell nanofiber hybrid scaffold for efficient suicide gene transfection and subsequent time resolved delivery of prodrug for anticancer therapy. ACS Applied Materials & Interfaces, 2015, 7, 18717–18731 (featured in “NATURE INDIA)

  42. I. Matai, A. Sachdev and P.Gopinath*. Self-assembled hybrids of fluorescent carbon dots and PAMAM dendrimers for epirubicin delivery and intracellular imaging. ACS Applied Materials & Interfaces, 2015,7,11423-11435

  43. P. Dubey, B. Bhushan, A. Sachdev, I. Matai, S. Uday Kumar and P.Gopinath*. Silver nanoparticles incorporated composite nanofiber for potential wound dressing applications. Journal of Applied Polymer Science, 2015132, 42473. (Cover page of the issue)

  44. P. Dubey, I. Matai, S. Uday Kumar, A. Sachdev, B. Bhushan and P.Gopinath*. Perturbation of cellular mechanistic system by silver nanoparticles toxicity: cytotoxic, genotoxic and epigenetic potential. Advances in Colloid and Interface Science, 2015, 221:4-21

  45. B. Bhushan and P.Gopinath*. Antioxidant nanozyme: A facile synthesis and evaluation of reactive oxygen species scavenging potential of nanoceria encapsulated albumin nanoparticles. Journal of Materials Chemistry B, 2015, 3, 4843-4852.

  46. S. Uday Kumar and P.Gopinath*. Controlled delivery of bPEI-niclosamide complexes by PEO nanofibers and evaluation of its anti-neoplastic potentials. Colloids and Surfaces B: Biointerfaces, 2015, 131:170-81.

  47. A. Sachdev and P.Gopinath*. Green synthesis of multifunctional carbon dots from coriander leaves and their potential application as antioxidants, sensors and bioimaging agents. Analyst, 2015, 140, 4260-4269.

  48. I. Matai, A. Sachdev and P.Gopinath*. Multicomponent 5-fluorouracil loaded PAMAM stabilized-silver nanocomposites synergistically induce apoptosis in human cancer cells. Biomaterials Science2015,3,457–468 (Cover page of the issue)

  49. A.Sachdev, I.Matai and P.Gopinath*. Dual-functional carbon dots-silver@zinc oxide nanocomposite: In vitro evaluation of cellular uptake and apoptosis induction. Journal of Materials Chemistry B, 2015,3,1208–1220 (Cover page of the issue)

  50. B. Bhushan, P. Dubey, S. Uday Kumar, A. Sachdev, I. Matai and P.Gopinath*. Bionanotherapeutics: Niclosamide Encapsulated Albumin Nanoparticles as a Novel Drug Delivery System for Cancer Therapy. RSC Advances, 2015,5,12078–12086 

  51. D. Malwal and P.Gopinath*. Fabrication and characterization of poly (ethylene oxide) templated nickel oxide nanofibers for dye degradation. Environmental Science: Nano, 2015,2,78–85

  52. S. Uday Kumar, I. Matai, P. Dubey, B. Bhushan, A. Sachdev and P.Gopinath*. Differentially cross-linkable core-shell nanofibers for tunable delivery of anticancer drugs: Synthesis, characterization and its anticancer efficacy. RSC Advances 2014, 4, 38263–38272.

  53. B. Bhushan, S. Uday Kumar, I. Matai, A. Sachdev, P.Dubey and P. Gopinath*,Ferritin Nanocages: A Novel Platform for Biomedical Applications.Journal of Biomedical Nanotechnology 2014,10,2950-2976.

  54. A. Sachdev, I. Matai and   P. Gopinath*. Implications of surface passivation on physicochemical and bioimaging properties of carbon dots. RSC Advances, 2014, 4,20915-20921.

  55. I. Matai, A. Sachdev, P. Dubey, S. Uday Kumar, B. Bhushan and P. Gopinath*, Antibacterial Activity and Mechanism of Ag-ZnO Nanocomposite on S.aureus and GFP-expressing Antibiotic Resistant E.coli. Colloids and Surfaces B: Biointerfaces 2014,115, 359–367.

  56. G. Bhargavi, I. Matai, A. Sachdev, S. Uday Kumar and P. Gopinath*,Microwave Assisted Synthesis of Chitosan Nanorods and Assessment of its Antibacterial Activity against GFP-Expressing Antibiotic Resistant E. coli. Journal of Chitin and Chitosan Science, 2013, 1, 1–6.

  57. A. Sachdev, I. Matai, S.Uday Kumar, B.Bhushan, P. Dubey and   P. Gopinath*. A novel one-step synthesis of PEG passivated multicolour fluorescent carbon dots for potential biolabeling application. RSC Advances, 2013, 3, 16958-16961.

  58. Sukumar UK, Bhushan B, Dubey P, Matai I, Sachdev A and P.Gopinath*. Emerging applications of nanoparticles for lung cancer diagnosis and therapy. International Nano Letters,2013, 3:45

  59. G. Sahni, P. Gopinath and P. Jeevanandam. A Novel Thermal Decomposition Approach to Synthesize Hydroxyapatite-Silver Nanocomposites and their Antibacterial Action against GFP-expressing Antibiotic Resistant E.coli. Colloids and Surfaces B: Biointerfaces  2013,Volume 103, Pages 441–447

  60. N. Kaur, N. Choudhary, R.N. Goyal ,S. Viladkar , I. Matai , P. Gopinath, S. Chockalingam ,D. Kaur. Magnetron sputtered Cu3N/NiTiCu shape memory thin film heterostructures for MEMS applications. Journal of Nanoparticle Research 2013,15:1468.

  61. V.K. Yata, P.Gopinath and S.S.Ghosh, Emerging Implications of Nonmammalian Cytosine Deaminases on Cancer Therapeutics. Applied Biochemistry and Biotechnology, 2012, 167(7):2103-16.

  62. P. Gopinath, S.K. Gogoi, P.Sanpui, A. Paul, A. Chattopadhyay  and S.S. Ghosh, Signaling Gene Cascade in Silver Nanoparticle Induced Apoptosis, Colloids and Surfaces B: Biointerfaces, 2010 Jun 1;77(2):240-5.

  63. Roman J, Rangasamy T, Guo J, Sugunan S, Meednu N, Gopinath Packirisamy, Shimoda L, Golding A,Semenza G and Georas SN, T Cell Activation Under Hypoxic Conditions Enhances Interferon-gamma Secretion, American Journal of Respiratory Cell and Molecular Biology ,2010, 42, 123-128.

  64. P. Gopinath and S.S.Ghosh, Understanding Apoptotic Signaling Pathways in Cytosine Deaminase-Uracil Phosphoribosyl Transferase Mediated Suicide Gene Therapy in vitro, Molecular and Cellular Biochemistry, 2009, 324, 21-29.

  65. P. Gopinath, S.K. Gogoi, A. Chattopadhyay  and S.S. Ghosh, Implications of Silver Nanoparticle Induced Cell Apoptosis for in vitro Gene Therapy, Nanotechnology , 2008, 19 (7).

  66. P. Gopinath and S.S.Ghosh, Implication of functional activity for determining therapeutic efficacy of suicide genes in vitro, Biotechnology Letters , 2008, 30, 1913-1921.

  67. P. Gopinath and S.S.Ghosh, Apoptotic Induction with Bifunctional E. coli Cytosine Deaminase- Uracil Phosphoribosyltransferase Mediated Suicide Gene Therapy Is Synergized By Curcumin Treatment in vitro, Molecular Biotechnology  , 2008, 39, 39-48.

  68. P. Gopinath and S.S. Ghosh, Monitoring green fluorescent protein for functional delivery of E. coli cytosine deaminase suicide gene and the effect of curcumin in vitro, Gene Therapy and Molecular Biology , 2007, 11, 219-228.

  69. S.K. Gogoi, P. Gopinath, A. Paul, A. Ramesh, S.S. Ghosh, and A. Chattopadhyay, Green Fluorescent Protein Expressing Escherichia coli as a model system for investigating the Antimicrobial activities of Silver Nanoparticles, Langmuir, 2006, 22, 9322-9328.

  70. S.S. Ghosh, P. Gopinath, and A. Ramesh, Adenoviral Vectors: A promising tool for Gene therapy, Applied Biochemistry and Biotechnology, 2006, 133 (1), 9-29.